Medical and Pharmaceutical Biotechnology master degree programme

Looking for an internationally respected master programme that will open up exciting career opportunities in the pharmaceutical industry and research? Potential employers hold our Medical and Pharmaceutical Biotechnology programme in high regard thanks its broad curriculum.

On the master programme you enhance your methods-based and problem-solving competencies, putting you in a position to overcome the challenges associated with developing and producing innovative treatments for cancer, autoimmune conditions and neurodegenerative diseases. You use cutting-edge and interdisciplinary methods, such as culturing “mini tumours” to help predict the effects of cancer treatments.

The degree programme: Master of Science in Engineering (MSc)

Our four-semester, English-language Medical and Pharmaceutical Biotechnology master degree programme is designed to provide you with extensive medical biotechnology knowledge and expertise in biotech product development and manufacturing.

An interdisciplinary approach is the key to success in biotechnology. To this end, you build on your knowledge of natural sciences, medical and engineering aspects. You also enhance your understanding of quality assurance frameworks, as well as learning how to combine knowledge from all of these disciplines.

The curriculum also features current trends and the latest developments: for instance, you use cutting-edge technologies, such as shotgun proteomics, to carry out a computerised bioinformatic analysis of all of a cell’s proteins under normal and pathological conditions.

Lecturers from European universities, international speakers from the pharmaceutical industry and plenty of lab work ensure that the programme has a strong practical focus and is aligned with the requirements of industry. When you graduate, you can choose from a wide range of career paths – the international nature of the programme opens up opportunities in the domestic and international job markets.

A particularly attractive option is the double degree we offer in conjunction with the Linköping University in Sweden. Besides obtaining a master of science at IMC Krems, you will also be accredited with completing the Experimental and Medical Biosciences programme at our partner institution.

Studium Medical and Pharmaceutical Biotechnology - Studierende steht hinter einer Glasfront und pipettiert

Studium Medical and Pharmaceutical Biotechnology - 2 Mitarbeiter vor einem Computer

Studium Medical and Pharmaceutical Biotechnology - 2 Studierende stehen im Labor

After completing your degree, you will be able start building a career in the international biotechnology industry or on a doctoral programme.

Programme director Harald Hundsberger

A formula for success: theoretical knowledge + practical experience

The programme is built on three pillars.

Advanced courses

Semesters 1-2

While the Medical and Pharmaceutical Biotechnology bachelor programme has a strong focus on the natural sciences, on the master programme the emphasis shifts to the methods-based and problem-solving skills required in the field.

In the first two semesters, you build on the knowledge you acquired on our bachelor degree or another related programme. Modules include Health, Disease and Therapeutical Strategies, Process Design, Bioprocess Technology and Analytical Methods in Life Sciences. You also start preparing for your research semester in semester 2.

On top of this, the Institute of Biotechnology hosts its annual Life Science Meeting, which is designed to be a very broad-based scientific conference. There’s always an exciting international atmosphere at this event, where you’ll benefit from the insights of globally respected scientists from research and industry. The programme also features presentations by our students and graduates.

The electives

Semester 3

In semester 3 you have the opportunity to tailor your degree according to your specific interests. You select one of two electives: Bioprocess Engineering or Advanced Therapeutics Development.

Both of these will give you an overview of the current research landscape: you learn about numerous research projects connected to your specialism and the Institute of Biotechnology’s research focuses.

This is a fantastic opportunity to become an expert in your chosen field: the elective you select will help give your professional profile a sharper focus. Ideally, in the next semester you will choose a research topic and internship placement linked to your specialism.

The research semester

Semester 4

The Applied Research Semester (ARTS) is a core element of the master programme. You spend at least 22 weeks at a respected biotechnology company or research facility in Austria or abroad. Examples include Massachusetts Institute of Technology (MIT) in the United States or Karolinska Institutet in Sweden. The focus of your work will be a project that forms the basis for your master thesis.

The research semester is timetabled for the final semester so you can draw on all the knowledge you have acquired across the full range of disciplines. This also gives you maximum flexibility in terms of completing your thesis – you’re able plan according to the requirements of the project.

After your research semester, you only have to return to university to take your final master examination. So if you’re offered a permanent job by your internship provider, this means there’ll be nothing standing in your way.

Curriculum

What can you expect from your studies? The curriculum provides an overview.

Click on the individual courses for further information.

Semester 1

Course	SWS	ECTS
Health, Disease and Therapeutical Strategies
Immunology	2	3
Immunology Module: Health, Disease and Therapeutical Strategies Root module: Health, Disease and Therapeutical Strategies Semester: 1 Course code: IMM1VO Contact hours per week: 2 ECTS: 3 Course Content: Basic techniques for laboratory-based scientific work Safety training and working with safety data sheets Introduction to laboratory equipment (glassware, etc.) Using laboratory equipment (e.g. scales, pH meters and spectrophotometers) Basic laboratory techniques Handling acids, bases and organic solvents Working with indicators Producing solutions and serial dilutions; calculating concentrations and estimating errors Course outcome: Upon completion of this course students are able to: explain the complex physiology of the immune system, summarize the activation of immune cells by pathogens in terms of mechanisms and systems, explain the complex function of the human immune system.
Hallmarks of Cancer	1	1
Hallmarks of Cancer Module: Health, Disease and Therapeutical Strategies Root module: Health, Disease and Therapeutical Strategies Semester: 1 Course code: HOC1VO Contact hours per week: 1 ECTS: 1 Course Content: The history of cancer research Molecular causes of cancer Genetic changes and their causes Fundamental molecular features of cancer development Multi-stage process of cell transformation Tumour-stromal interactions Metastasis Tumour immunology Tumour metabolism Targeted therapies and personalised medicine Tumour engineering and drug development Course outcome: Upon completion of this course students are able to: explain the molecular causes of cancer, explain and analyze the complex events when healthy tissue is transformed into malignant tissue, explain and interpret new therapeutic approaches aimed at treating cancer and immunological disorders.
Molecular Mechanisms of Ageing	1	1
Molecular Mechanisms of Ageing Module: Health, Disease and Therapeutical Strategies Root module: Health, Disease and Therapeutical Strategies Semester: 1 Course code: MMA1VO Contact hours per week: 1 ECTS: 1 Course Content: The ageing process in cells The ageing process in living organisms Theories and molecular mechanisms of ageing Genetic programming for ageing Environmental factors and genetic predisposition Premature ageing: selected examples and molecular causes of the condition Lifestyle, stress and hormonal status Age-related diseases and their causes Course outcome: Upon completion of this course students are able to: explain the functional relationships between the genome, embryogenesis, ageing processes, environmental factors and diseases, explain and analyze the complex events in cells an tissues when aging takes place, explain the physiology of ageing and associated diseases.
Developmental Biology	1	1
Developmental Biology Module: Health, Disease and Therapeutical Strategies Root module: Health, Disease and Therapeutical Strategies Semester: 1 Course code: DBIO1VO Contact hours per week: 1 ECTS: 1 Course Content: Fundamentals and mechanisms of embryogenesis Early embryogenesis and topological patterning of the axes (fertilisation, initial cell division, morula, gastrulation and neurulation) Late embryogenesis (organ development from ectoderm, mesoderm and endoderm) Embryonic models for drug development Somatic cell reprogramming and regenerative medicine Course outcome: Upon completion of this course students are able to: analyze the functional relationships between the genome, embryogenesis, ageing processes, environmental factors and diseases, explain the molecular mechanisms of embryogenesis, use embryonic animal models for testing active ingredients.
Bioethics
Bioethics	1	1
Bioethics Module: Bioethics Root module: Bioethics Semester: 1 Course code: BETH1WK Contact hours per week: 1 ECTS: 1 Course Content: The ethics of end-of-life decision making Embryo screening Predictive medicine Transplantation medicine Legal issues Stem cells Assisted dying Moderated discussions on relevant topics Course outcome: Upon completion of this course students are able to: evaluate and discuss social and scientific aspects of applications of genetic engineering as well as bioethical issues, evaluate and find solutions to legal questions related to bioethics, evaluate and apply statutory regulations connected with bioethics and human dignity.
Process Design
Equipment and Production Design	2	3
Equipment and Production Design Module: Process Design Root module: Process Design Semester: 1 Course code: EPD1VO Contact hours per week: 2 ECTS: 3 Course Content: •Specifications (facilities, product, instrumentation), analytical systems (e.g. sensors) Costing and design of utility systems (gas and air supply, water for injection, cooling and heating mediums) IQ, OQ, PQ, URS, process qualification Inspection, acceptance and commissioning of production facilities (cleaning, water runs, sterility and conformity testing) Process standards Media design (complex, defined) including media preparation and sterilisation techniques (in situ, ex situ) Inoculum preparation and fermentation management; microbial organisms vs. mammalian cells Fermentation kinetics (e.g. product formation rate, glucose uptake rate, oxygen requirements and energy input) Students independently complete exercises on media preparation planning, calculation of parameters for reaction kinetics, sterilisation times and microorganism kill rates, and for the efficiency of virus removal steps, as well as preparing sampling plans using the kinetics data to compile batch records. Course outcome: Upon completion of this course students are able to: plan the basic features of biotechnology production facilities, explain standards and families of standards applicable in Austria and abroad, and interpret them accordingly, apply integrated knowledge of production facility design to achieve precisely defined product quality parameters.
Standardization	1	2
Standardization Module: Process Design Root module: Process Design Semester: 1 Course code: ST1VO Contact hours per week: 1 ECTS: 2 Course Content: Overview of the development of company specification standards based on national and international standards Specifications Standards (open, proprietary, basic, product, planning and service) Distinction between specifications, standards, regulation and company standards The standardisation process National standards (ÖNORM, DIN) International standards (ISO, CEN) Structural design of standards Dealing with national and international standards in the course of routine work in the biotechnology industry Legal aspects of standardisation Distinction between standardisation and accreditation The accreditation process Course outcome: Upon completion of this course students are able to: explain standards and families of standards applicable in Austria and abroad, and interpret them accordingly, explain and apply legal aspects of product standardisation based on national and international standards.
Biomedical Regulatiuons
Legislation for Drugs and Medical Devices	2	3
Legislation for Drugs and Medical Devices Module: Biomedical Regulatiuons Root module: Biomedical Regulatiuons Semester: 1 Course code: LDMD1VO Contact hours per week: 2 ECTS: 3 Course Content: Pharmaceuticals legislation in Europe and the US Definition of pharmaceuticals and important distinctions Development and lifecycles of pharmaceuticals Quality aspects of pharmaceuticals, safety and efficacy Structure and content of specialist and patient information Pharmaceuticals approval process in Europe and the US Maintaining approval Generic drugs, internet and product liability Pharmacovigilance Pharmaceuticals marketing and sales Medical Products Act: requirements for medical products (harmonised standards, CE marking, carrying out conformity assessments) Classification of medical products Course outcome: Upon completion of this course students are able to: apply the legislation and related regulatory regimes for pharmaceuticals in Europe and the US (EMDA, FDA), apply statutory guidelines and patent restrictions pertaining to biomedical products during their lifecycle.
Bioprocess Technology
Upstream and Downstream Processing
Upstream Processing	1	2
Upstream Processing Module: Upstream and Downstream Processing Root module: Bioprocess Technology Semester: 1 Course code: UP1VO Contact hours per week: 1 ECTS: 2 Course Content: Students learn about the processes involved in preparing and managing fermentation with microbiological organisms and mammalian cells. The lectures will cover: • Different useful Host Organisms, their advantages and disadvantages • Fermentation kinetics (e.g. product formation rate, glucose fermentation rate, oxygen requirements and energy input) • Calculations describing fermentations (Mass Balancing, Feed Calculations, Heat Generation and Dissipation) • Fermentation process development and scaling based on different parameters Students perform calculations of parameters for reaction kinetics, feeding and heat dissipation based on typical sets of information given in the industrial environment. Course outcome: Upon completion of this course students are able to: explain technical equipment requirements and process parameters, and classify their application principles.
Downstream Processing	1	2
Downstream Processing Module: Upstream and Downstream Processing Root module: Bioprocess Technology Semester: 1 Course code: DP1VO Contact hours per week: 1 ECTS: 2 Course Content: Students learn about the processes involved in preparing and managing downstream processes of recombinant products comming from microbiological organisms and mammalian cells. The lectures will cover: Cell breakup Primary recovery Different separation principles (mainly chromatography but also christallization) and their scaling preparation for fill and finish Course outcome: Upon completion of this course students are able to: explain and design primary recovery steps, design downstream processes including several purification steps, explain the scaling of primary recovery and purification, design preparation for fill and finish.
Recombinant Protein Production - Theory	2	3
Recombinant Protein Production - Theory Module: Bioprocess Technology Root module: Bioprocess Technology Semester: 1 Course code: RPPT1ILV Contact hours per week: 2 ECTS: 3 Course Content: Overview of the most frequently used protein production organisms for research and industrial applications General principles of protein production Impact of biochemical properties of proteins, their amino acids and chemical modifications on protein production and protein purification Comparison and discussion of standard protein purification strategies Course outcome: Upon completion of this course students are able to: name the principles of the key methods of protein purification and compare their advantages and disadvantages, compare biopharmaceutical production and/or purification strategies.
Recombinant Protein Production - Laboratory	4	4
Recombinant Protein Production - Laboratory Module: Bioprocess Technology Root module: Bioprocess Technology Semester: 1 Course code: RPPL1LB Contact hours per week: 4 ECTS: 4 Course Content: Demonstration of the principles of gene expression/protein production in the Pichia pastoris production organism demonstrated using a cytokine Purification of a cytokine Using this protein to learn about typical methods of biochemical analysis for the characterisation of proteins Specific content includes transformation of yeast cells, expression of cytokine genes from an inducible promoter, breaking open cells and obtaining cell extract, purification of the desired protein using affinity chromatography, defining the protein concentration, visualisation of the protein using western blotting, tests to characterise the bioactivity of the protein. Course outcome: Upon completion of this course students are able to: apply their knowledge of the points above in a laboratory environment, independently develop biopharmaceutical production and/or purification strategies.
Research Project in Industry and Master Thesis
Research Project - Preparation	1	1
Research Project - Preparation Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 1 Course code: RPP1WK Contact hours per week: 1 ECTS: 1 Course Content: Updating CVs and covering letters Career and internship opportunities in industry and research Coaching support with research semester applications Course outcome: Upon completion of this course students are able to: develop arguments to support an application and write application documents, identify and analyse the requirements of prospective employers or internship providers, select research projects suited to their chosen future career, evaluate possible future career paths.
Focal Subject - Elective 1: Bioprocess Engineering
Elective 1: Bioprocess Engineering
Process Control and Process Online Monitoring	2	3
Process Control and Process Online Monitoring Module: Elective 1: Bioprocess Engineering Root module: Elective 1: Bioprocess Engineering Semester: 1 Course code: PCPOM1VO Contact hours per week: 2 ECTS: 3 Course Content: Theoretical principles and technical options in process control Theoretical principles of the measurement, control, regulation, properties and operation of probes Selecting and monitoring critical measurement parameters Automated process definition Process mapping Input-process-output diagrams Process flow diagrams Value stream mapping Top-down charts Swimlane diagrams Process performance Process capability and stability Cp and Cpk Sigma quality levels Simulation calculations and practical exercises Course outcome: Upon completion of this course students are able to: explain the monitoring of up-to-date production processes, identify appropriate instrumentation for the online control and monitoring of processes.
Focal Subject - Elective 2: Advanced Therapeutics Development
Elective 2: Advanced Therapeutics Development
Drug Discovery Systems	2	3
Drug Discovery Systems Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 1 Course code: DDS1VO Contact hours per week: 2 ECTS: 3 Course Content: Biochemical and biophysical assays for drug discovery 3D cell culture techniques for drug discovery Development of small molecular weight compounds High-throuput- and high-content screening Marine organisms as sources of new therapeutic agents Course outcome: Upon completion of this course students are able to: explain major principles applied in drug discovery, compare cutting edge drug discovery methods, illustrate and compare methods of characterising newly discovered drugs, summarize the different phases of the drug discovery process.

Semester 2

Course	SWS	ECTS
Integrative Methods in Biotechnology
Biostatistics and Trend Analysis	1	2
Biostatistics and Trend Analysis Module: Integrative Methods in Biotechnology Root module: Integrative Methods in Biotechnology Semester: 2 Course code: BTA2ILV Contact hours per week: 1 ECTS: 2 Course Content: Precision and reliability of confidence limits Significance tests (T-tests, chi squared test, F-test and non-parametric alternatives) Variance analysis (parametric and non-parametric) Trend analysis Analysis of contingency tables Course outcome: Upon completion of this course students are able to: use biostatistics to address common biotechnology questions, explain physical values that have a significant effect on biotechnological processes.
Systems Biology	1	1
Systems Biology Module: Integrative Methods in Biotechnology Root module: Integrative Methods in Biotechnology Semester: 2 Course code: SBIO2ILV Contact hours per week: 1 ECTS: 1 Course Content: The concept of systems biology Areas of overlap with other disciplines and network theories Forthcoming high-throughput technologies Interactions between components of cellular systems Applications of systems biology strategies for the development of therapies and identification of drug targets Course outcome: Upon completion of this course students are able to: explain the complex interactions of biomolecular networks, explain methods for analysing biomolecular networks.
Structural Bioinformatics and Drug Design	2	2
Structural Bioinformatics and Drug Design Module: Integrative Methods in Biotechnology Root module: Integrative Methods in Biotechnology Semester: 2 Course code: SBDD2VO Contact hours per week: 2 ECTS: 2 Course Content: Biomolecules: basic biochemical and biophysical principles Structural alignment of biomolecules Experiment-based structural determination of biomolecules Predicting biomolecular structural features Modelling the 3D structure of biomolecules Principles and common methods of drug design Course outcome: Upon completion of this course students are able to: examine the links between the structure and function of biomolecules, analyse and compare the 3D structure of biomolecules, use calculations for properties of biomolecules, apply selected drug design methods.
Analytical Methods in Life Science
Bioanalytics Laboratory	2	3
Bioanalytics Laboratory Module: Analytical Methods in Life Science Root module: Analytical Methods in Life Science Semester: 2 Course code: BAL2LB Contact hours per week: 2 ECTS: 3 Course Content: Mass spectroscopy gene knock down with siRNA in mammalian cells followed by analysis of the proteome bioinformatic analyis of proteomic data gene clustering and visualization of pathways identification of putative targets Course outcome: Upon completion of the course, students are able to: apply practical organic separation and detection skills and synthesise simple organic compounds, apply documentation on synthesis reactions and estimate the related risks.
Personalized Medicine Laboratory	2	3
Personalized Medicine Laboratory Module: Analytical Methods in Life Science Root module: Analytical Methods in Life Science Semester: 2 Course code: PML2LB Contact hours per week: 2 ECTS: 3 Course Content: DNA and RNA isolation and analysis cDNA synthesis Real-time quantitative PCR (qPCR) with SYBR® Green and TaqMan™ probes (comparison) Gene expression analysis Allele-specific qPCR SNP analysis High-resolution melting curve analysis PCR RFLP Pyrosequencing Course outcome: Upon completion of this course students are able to: apply practical organic separation and detection skills and synthesise simple organic compounds, apply documentation on synthesis reactions and estimate the related risks.
Analytical Methods in Biomedicine	2	3
Analytical Methods in Biomedicine Module: Analytical Methods in Life Science Root module: Analytical Methods in Life Science Semester: 2 Course code: AMB2VO Contact hours per week: 2 ECTS: 3 Course Content: Methods of real-time qPCR (including primer design in the PC lab) and their applications (gene expression analysis, allele-specific qPCR) Methods of identifying genetic variations (e.g. sequencing, pyrosequencing and massive parallel sequencing) – personalised medicine Analysis of epigenetic modifications DNA-protein interactions (ChIP, EMSA, DNase footprint) Flow cytometry Cell fractionation Analysis of post-translational modifications (phosphorylation, glycosylation, ubiquitination) Course outcome: Upon completion of this course students are able to: explain gene expression analyses at the RNA and protein levels, and present them in academic texts, explain epigenetic modifications and formulate hypotheses on their effects, explain methods of practical organic separation.
Fundamentals in Pharmaceutical Sciences
Pharmacokinetics and Pharmacodynamics	2	3
Pharmacokinetics and Pharmacodynamics Module: Fundamentals in Pharmaceutical Sciences Root module: Fundamentals in Pharmaceutical Sciences Semester: 2 Course code: PP2VO Contact hours per week: 2 ECTS: 3 Course Content: General pharmacology Quantifying the effects of pharmaceuticals Concentration-effect relationships for in vitro and in vivo models Characterisation of agonists and antagonists Molecular mechanisms of action and target proteins in pharmaceuticals Types of receptor, receptor subtypes, pharmacodynamic and pharmacokinetic causes of resistance Pharmacological studies in preclinical pharmaceutical development Use of animal models Pharmacological studies in clinical development ADME: fundamental principles of resorption, distribution, metabolism, and excretion of pharmaceuticals Determining ADME parameters in practice Phases of clinical trials Preparation of investigator's brochures Course outcome: Upon completion of this course students are able to: compare the principles and key areas of pharmacodynamics and pharmacokinetics, analyse pharmacodynamic and pharmacokinetic parameters, explain the molecular mechanism of action of pharmaceuticals, evaluate the role of pharmacodynamics and pharmacokinetics as part of pharmaceutical development, summarize how animal models are used in pharmacology.
Quality Management and Regulations in Biotechnology
GLP, GMP and Risk Assessment
GLP and GMP Regulations	1	1
GLP and GMP Regulations Module: GLP, GMP and Risk Assessment Root module: Quality Management and Regulations in Biotechnology Semester: 2 Course code: GGR2VO Contact hours per week: 1 ECTS: 1 Course Content: Statutory quality assurance regulations in the pharmaceutical industry OECD Principles of Good Laboratory Practice (GLP); applicability of the study plan and study report EU Guide to GMP and CFR 210/211; applicability of the GMP regulation Setting up a product facility Regulations relating to personnel, production, documentation, quality control and QM QM during the biotechnological development process Testing of active substances and additives Formulation development, developing production processes; form of administration and container closure systems Microbial controls; compatibility QM in the pharmaceutical industry: ICH Q8,Q9 and Q10 Course outcome: Upon completion of this course students are able to: name and apply statutory pharmaceutical quality assurance regulations applicable in the preclinical, clinical and production phases, explain and apply audit systems.
Risk Assessment	1	1
Risk Assessment Module: GLP, GMP and Risk Assessment Root module: Quality Management and Regulations in Biotechnology Semester: 2 Course code: RA2VO Contact hours per week: 1 ECTS: 1 Course Content: Risk management in accordance with ICH Q9 and other guidelines Methods of risk assessment: preliminary risk analysis: Preliminary hazard analysis (PHA), event tree analysis (ETA), failure mode and effect analysis (FMEA), fault tree analysis (FTA), HAZOP (hazard and operability studies) Corrective measures: HAZOP Critical control point hazard analysis and critical point methodology (HACCP) Risk management and reliability planning, risk assessment for development projects, environmental risk assessment Course outcome: Upon completion of this course students are able to: apply various risk assessment methods in the context of the pharmaceutical and biotechnology industries.
Quality Management Systems	1	1
Quality Management Systems Module: Quality Management and Regulations in Biotechnology Root module: Quality Management and Regulations in Biotechnology Semester: 2 Course code: QMS2VO Contact hours per week: 1 ECTS: 1 Course Content: Quality management systems, standards and guidelines, comparison of ISO, ICH and GMP Statistical methods and elements of QM Principles of QM and its elements Auditing quality management systems; principles and methods Course outcome: Upon completion of this course students are able to: explain and interpret quality assurance methods for pharmaceutical products, explain various aspects of quality management (QM) systems, apply and analyse statistical methods for QM systems, explain and apply audit systems.
Pharmaceutical Project Management
Project and Portfolio Management	1	1
Project and Portfolio Management Module: Pharmaceutical Project Management Root module: Pharmaceutical Project Management Semester: 2 Course code: PPMGT2VO Contact hours per week: 1 ECTS: 1 Course Content: Key aspects of project management in the pharmaceutical industry Portfolio management Corporate strategy Project structure planning, work packages, project network diagrams, critical path analysis Managing integration Developing biotechnological pharmaceuticals Course outcome: Upon completion of this course students are able to: plan and implement pharmaceutical industry projects, generate project plans with work packages.
Clinical Studies and GCP	1	1
Clinical Studies and GCP Module: Pharmaceutical Project Management Root module: Pharmaceutical Project Management Semester: 2 Course code: CSGCP2VO Contact hours per week: 1 ECTS: 1 Course Content: Clinical trials: phases and management Setting up and monitoring clinical trials Quality standards for clinical trials Interface management during trials, academic versus industry-funded research Risk-benefit analysis Investigational product management Project management in clinical trials Course outcome: Upon completion of this course students are able to: evaluate the regulations applicable to particular clinical trials and apply them in the course of the respective project, devise a set-up for carrying out clinical trials.
Entrepreneurship in Life Sciences	2	2
Entrepreneurship in Life Sciences Module: Pharmaceutical Project Management Root module: Pharmaceutical Project Management Semester: 2 Course code: ELS2ILV Contact hours per week: 2 ECTS: 2 Course Content: Students will be introduced to the business side of setting up a new company and key management processes. Business aspects of start-ups: Analysis of the business environment (analysis of the market, environment, location as well as legal, political and technical considerations) Choice of legal form Drawing up a business plan Cost accounting: Designing a cost accounting and cost-type system Cost-centre accounting Cost unit accounting (calculation), analysis of operating profit Management control: Budgeting Budgets and financial plans Objectives, tasks and functions of management control Management indicators Analysing annual financial statements Management case studies Course outcome: Upon completion of this course students are able to: exemplify an overview of business processes, explain underlying legal frameworks, explain how business processes can be managed.
Focal Subject - Elective 1: Bioprocess Engineering
Elective 1: Bioprocess Engineering
Fermentation and Scale Up - Scale Down Techniques
Fermentation of Complex Host Systems	1	1
Fermentation of Complex Host Systems Module: Fermentation and Scale Up - Scale Down Techniques Root module: Elective 1: Bioprocess Engineering Semester: 2 Course code: FCHS2VO Contact hours per week: 1 ECTS: 1 Course Content: Fermentation of extremophile organisms Co-cultivation of organisms Mammalian cell fermentation Use of alternative carbon (C) sources with specialised organisms New types of host systems (content selected by the available visiting experts) Course outcome: Upon completion of this course students are able to: analyse and optimise the progress of fermentation and solve problems that arise, operate a process control system and program simple operations.
Scale Up - Scale Down Techniques	1	2
Scale Up - Scale Down Techniques Module: Fermentation and Scale Up - Scale Down Techniques Root module: Elective 1: Bioprocess Engineering Semester: 2 Course code: SUSDT2VO Contact hours per week: 1 ECTS: 2 Course Content: Purification steps for biopharmaceutical products and methods for shifting from laboratory-scale to pilot-plant or production scale processes The four main operations in downstream production: removal of insolubles, product isolation, product purification and product polishing Filtration, lysis and flocculation, sedimentation, extraction, chromatography and adsorption, precipitation, crystallisation, spray drying and centrifugation Dimensionless indicators and an introduction to dimensional analysis Calculation exercises: characterisation of individual purification steps and scaling up elements of facilities Application of scale-down models for process modelling to resolve problems with current production processes Course outcome: Upon completion of this course students are able to: explain common techniques and purification strategies for the production of biopharmaceuticals, explain key requirements for technical equipment, the key process parameters and their determination, as well as the adaptation of process strategies according to the production organism and the properties of the biopharmaceutical product, apply this knowledge in simple examples, analyse problems in relation to the areas mentioned above.
Fermentation Technology - Laboratory I	2	3
Fermentation Technology - Laboratory I Module: Elective 1: Bioprocess Engineering Root module: Elective 1: Bioprocess Engineering Semester: 2 Course code: FTLI2LB Contact hours per week: 2 ECTS: 3 Course Content: Fermentation of different host systems in different operational modes (Batch, Fed-Batch) Sampling (online, atline and offline) and corresponding analytics Analyzing and judging of analytical data Applying the theoretical knowledge and data to control and optimize the fermentation Primary recovery based on the fermentation process Purifying of recombinant proteins Course outcome: Upon completion of this course students are able to: explain and apply advanced fermentation knowledge to develop and optimize fermentation processes with different host organisms, explain and apply primary recovery knowledge to develop and optimize this process step, explain and apply purification of proteins knowledge to develop and optimize this process step.
Focal Subject - Elective 2: Advanced Therapeutics Development
Elective 2: Advanced Therapeutics Development
Advanced Therapeutic Developement Laboratory I	2	3
Advanced Therapeutic Developement Laboratory I Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 2 Course code: ATDLI2LB Contact hours per week: 2 ECTS: 3 Course Content: Establishment and validation of Assays for HCS High-throughput Screening: theoretical and practical programming of an HT device (liquid handling & automation Course outcome: Upon completion of this course students are able to: generate and validate complex Assays for HCS, explain, analyse and discuss the latest trends in HCS, programm and use a HT-device.
Pathophysiology and Molecular Therapies	2	3
Pathophysiology and Molecular Therapies Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 2 Course code: PMT2VO Contact hours per week: 2 ECTS: 3 Course Content: Pathology of selected example illnesses State-of-the-art therapy strategies Developing new therapy concepts Standard strategies and future approaches to vaccination Development and application of the latest mouse models Course outcome: Upon completion of this course students are able to: explain/illustrate selected example illnesses and describe their pathophysiology, explain and compare state-of-the-art therapy strategies and new therapy concepts.

Semester 3

Course	SWS	ECTS
Focal Subject - Elective 1: Bioprocess Engineering
Elective 1: Bioprocess Engineering
Equipment Test and Process Validation	2	4
Equipment Test and Process Validation Module: Elective 1: Bioprocess Engineering Root module: Elective 1: Bioprocess Engineering Semester: 3 Course code: ETPV3VO Contact hours per week: 2 ECTS: 4 Course Content: <ul> <li>Fundamentals of equipment, test and process validation based on legal guidelines and using practical examples</li> <li>Design qualification</li> <li>User requirements specification</li> <li>Functional specifications</li> <li>Installation qualification (IQ), drawing up IQ plans</li> <li>Operational qualification (OQ)</li> <li>Drawing up OQ plans</li> <li>Performance qualification</li> <li>Retrospective qualification</li> <li>Requalification</li> <li>Maintaining qualification status</li> <li>Process validation</li> <li>Defining the scope of a validation, risk analysis</li> <li>Validation master plan and validation matrix</li> <li>Cleaning validation</li> <li>Optimising cleaning procedures and drafting cleaning policies</li> <li>Cleaning validation master plan</li> <li>Defining the scope of validation</li> <li>Acceptance criteria, computer validation</li> <li>Prospective and retrospective validation, validation master plan</li> <li>Operating computerised systems</li> </ul> Course outcome: Upon completion of this course students are able to: analyse offline analytical tests for the quality control of biopharmaceuticals, use the knowledge outlined above to optimise processes and identify and solve problems that arise in this context, design test documentation, use and plan equipment and devices in the context of pharmaceutical applications, design experimental designs and parameters for the validation of simple tests and items of equipment, design and evaluate test specifications and reports.
Fermentation Technology - Laboratory II	5	11
Fermentation Technology - Laboratory II Module: Elective 1: Bioprocess Engineering Root module: Elective 1: Bioprocess Engineering Semester: 3 Course code: FTLII3LB Contact hours per week: 5 ECTS: 11 Course Content: Fermentation of single cell organisms Operating process control systems Working with bioreactors under sterile conditions Offline measurement methods Online measurement methods Calculating fermentation control parameters Preparing defined and complex media Sterile addition methods Troubleshooting Analysis of fermentation parameters Evaluating parameters to arrive at a process management approach Setting up, dismantling and maintaining bioreactors Analytical methods of evaluation (e.g. electrophoresis, FPLC and ELISA) Cell disruption methods Course outcome: Upon completion of this course students are able to: explain basic and andvanced principles of fermentation and the use of fermentation technology in a near-industrial context, apply this knowledge to manage fermentation processes, use fermentation measurement data to inform subsequent process management decisions.
Focal Subject - Elective 2: Advanced Therapeutics Development
Elective 2: Advanced Therapeutics Development
Stem Cells, Gene Therapy and Regenerative Medicine	1	3
Stem Cells, Gene Therapy and Regenerative Medicine Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 3 Course code: SCGTRM3VO Contact hours per week: 1 ECTS: 3 Course Content: Stem cells for therapeutic applications Principles of cell and tissue therapy Principles of gene therapy and its applications Tissue engineering techniques Examples of cell and tissue therapy applications Course outcome: Upon completion of this course students are able to: identify and classify the properties of different types of stem cell, explain the therapeutic applications of stem cells and other types of cell, and discuss the latest trends in stem cell research.
Immunology Based Therapies	1	1
Immunology Based Therapies Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 3 Course code: IBT3VO Contact hours per week: 1 ECTS: 1 Course Content: Key properties of immune cells for immune therapy Immune therapy techniques Examples of immune therapy application Course outcome: Upon completion of this course students are able to: compare therapeutic approaches in regenerative medicine, explain the principles of gene therapy and discuss their application, explain and compare strategies for immune-based therapies.
Advanced Therapeutic Developement Laboratory II	5	11
Advanced Therapeutic Developement Laboratory II Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 3 Course code: ATDLII3LB Contact hours per week: 5 ECTS: 11 Course Content: Isolation and characterization of a state-of-the-art bioactive, therapeutic biomolecule Quality control of this product Characterisation of the product’s functionality (Cell-based Assays) Course outcome: Upon completion of this course students are able to: use methods for the isolation and characterization of therapeutic agents in the laboratory, examine their function of biomolecules using laboratory experiments, discuss the latest trends in the development of therapeutic agents, identify and evaluate potential fields of application.
Research Project in Industry and Master Thesis
Master Thesis - Part I	1	4
Master Thesis - Part I Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 3 Course code: MTI3DA Contact hours per week: 1 ECTS: 4 Course Content: Writing the proposal for the master thesis Practical work and data analysis Course outcome: Upon completion of this course students are able to: Write a master thesis proposal in accordance with the applicable guidelines, Perform the practical work, Analyze the achieved data, independently carry out a research project on a topical theme in a real-life business, biotechnology and/or biomedical working environment.
Master Thesis - Coaching Seminar I	1	1
Master Thesis - Coaching Seminar I Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 3 Course code: MTCI3TU Contact hours per week: 1 ECTS: 1 Course Content: Discussion, feedback and quality assurance of the master thesis proposal Course outcome: Upon completion of this course students are able to: prepare, plan and discuss a scientific project in an appropriate manner.
Research Project	1	10
Research Project Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 3 Course code: RP3SE Contact hours per week: 1 ECTS: 10 Course Content: Literature research Definition of topic for the master thesis Definition of Scientific Methods for the Master thesis Course outcome: Upon completion of this course students are able to: read and evaluate scientific literature, generate and plan a research project, independently carry out a research project on a topical theme in a real-life business, biotechnology and/or biomedical working environment.

Semester 4

Course	SWS	ECTS
Focal Subject - Elective 1: Bioprocess Engineering
Elective 1: Bioprocess Engineering
Current Issues in Bioprocess Engineering	1	2
Current Issues in Bioprocess Engineering Module: Elective 1: Bioprocess Engineering Root module: Elective 1: Bioprocess Engineering Semester: 4 Course code: CIBE4SE Contact hours per week: 1 ECTS: 2 Course Content: Literature research on the latest trends in the relevant fields Reviewing the relevant literature Presentation of results Discussion of the contents of the literature selected Course outcome: Upon completion of this course students are able to: explain the actual state of research in the corresponding field, apply their knowledge to the actual problems in research and industry.
Focal Subject - Elective 2: Advanced Therapeutics Development
Elective 2: Advanced Therapeutics Development
Current Issues in Advanced Therapeutic Developement	1	2
Current Issues in Advanced Therapeutic Developement Module: Elective 2: Advanced Therapeutics Development Root module: Elective 2: Advanced Therapeutics Development Semester: 4 Course code: CIATD4SE Contact hours per week: 1 ECTS: 2 Course Content: Literature research on the latest trends in the relevant fields Reviewing the relevant literature Presentation of results Discussion of the contents of the literature selected Course outcome: Upon completion of this course students are able to: explain the actual state of research in the corresponding field, apply their knowledge to the actual problems in research and industry.
Research Project in Industry and Master Thesis
Master Thesis - Part II	1	18
Master Thesis - Part II Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 4 Course code: MTII4DA Contact hours per week: 1 ECTS: 18 Course Content: Practical work and data analysis Summary and evaluation of the scientific data in a master thesis Course outcome: Upon completion of this course students are able to: examine and critically discuss literature related to the topic or research problem, Perform the practical work, compile and evaluate data for the purpose of addressing the research problem/s, discuss and critically reflect on findings, independently complete a scientifc paper in form of the master thesis.
Master Thesis - Coaching Seminar II	1	6
Master Thesis - Coaching Seminar II Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 4 Course code: MTCII4TU Contact hours per week: 1 ECTS: 6 Course Content: Discussion, feedback and quality assurance of the master thesis proposal Course outcome: Upon completion of this course students are able to: prepare, plan and discuss a scientific project in an appropriate manner.
Master Exam	0	4
Master Exam Module: Research Project in Industry and Master Thesis Root module: Research Project in Industry and Master Thesis Semester: 4 Course code: MEX4AP Contact hours per week: 0 ECTS: 4 Course Content: Presentation of the master thesis Oral examination on the Master thesis and links to related subjects on the curriculum Course outcome: Upon completion of this course students are able to: present their master thesis and the question they addressed in a manner appropriate to the target audience, and defend the thesis before an expert committee, outline the significance of the findings for professional practice and research, and present supporting arguments, answer follow-up questions on degree-programme subjects and the links between them, and justify their answers.

Electives

Choose your own focus areas: you select one of two electives on the master programme.

Bioprocess Engineering

This elective prepares you for work in the development and manufacture of pharmaceutical products.

Today, these products are frequently produced using biopharmaceutical techniques, by means of fermentation in large bioreactors. This requires genetically modified microorganisms, which are cultured in very high cell densities to manufacture the desired product. Such products range from medicines to ingredients for nutritional supplements, as well as substances like bioethanol.

If you take this elective, you will gain detailed insights into bioprocess engineering, process automation, and especially fermentation. This expertise will give you the skills required to take on positions at all types of biotech company – large pharmaceutical businesses as well as small start-ups specialising in innovative products such as nutraceuticals. You’ll be able to contribute in a wide range of areas encompassing the development, testing and large-scale manufacturing of brand new substances.

In the bioprocess engineering lectures and practicals you’ll use cutting-edge analytical techniques, ranging from simple online methods – which you’ll also evaluate – through to liquid LC-MS for proteomics work.

Advanced Therapeutics Development

This elective takes an in-depth look at research into active ingredients and their mechanisms. It lays the foundations for a PhD in a related area or a job in an R&D department in the biotech industry.

Medical biotechnology has seen some major breakthroughs in recent years, such as immune checkpoint inhibitors (PD-1) for the treatment of advanced melanomas. Small interfering RNA (siRNA) molecules are currently being tested for use in potential treatments for cancers and viral diseases, which are expected to come on to the market in the next few years.

High-throughput technologies in areas such as next-generation sequencing (NGS), mass spectrometry and imaging are becoming increasingly important in the development of new treatments. This means there is going to be an ever greater focus on linking together large data sets, and integrating the clinical results of treatment.

The Advanced Therapeutic Development elective module gives you a solid grounding in these areas. This is reinforced with a lab-based course linked to the elective, in which you reproduce the early stages of the drug development process. A journal club on topical biotechnology questions rounds out the programme.

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Career paths

As a graduate of the Medical and Pharmaceutical Biotechnology master programme you will be especially well placed to assume positions at pharmaceutical and biotechnology companies or medical research institutes.

You can also opt to take a PhD at a university in Austria or abroad. We have PhD cooperation agreements with Danube University Krems and the University of Veterinary Medicine, Vienna. These agreements ensure that admission to the PhD programmes at these institutions is a straightforward process.

The professional areas open to graduates include:

R&D responsibilities in research and industry

clinical trials and drug approval

planning and management of biotechnological processes (fermentation)

biomedical and analytical testing procedures

coordination responsibilities in production, quality control, quality assurance and approval

marketing and sales

medical engineering

food technology and food safety

industrial and environmental biotechnology

10 good reasons

What makes us special? We are more than happy to tell you about the aspects of our university, which we are especially proud of.

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Krems

Friendly and cosmopolitan: The city attracts students from all over the world, who come to study, research and work together.

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Service centers

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Advisory Service

Do you have questions regarding our degree programmes or the application? Contact our Prospective Student Advisory Service.

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Opinions: Medical and Pharmaceutical Biotechnology

Click through the videos of the degree programme.

Graduate Patricia Wildberger

Virtual Info Day

Our info events

Saturday
22.02.2020
09:00
Open House
All information about the bachelor and master degree programmes at IMC Krems.
IMC Campus Krems, Wing G1 IMC Campus Krems, Wing G1

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Our team

Get to know the core team of our master degree programme Medical and Pharmaceutical Biotechnology.

Prof.(FH) Priv.-Doz. Mag. Dr. Harald Hundsberger
Head of Institute Biotechnology / Programme Director Medical and Pharmaceutical Biotechnology
Institute Biotechnology
Contact
+43 2732 802 521[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (2)
Recombinant Protein Expression, Cell Culture Models, Peptide Engineering,
Instrument Development
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (14)
Extrazelluläre Vesikel aus dem Hoffa-Fettkörper - ein neuer Ansatz der Knorpelregeneration?
Department of Life Sciences
Testung von rekombinanten polyklonalen Antikörperfragmenten gegen Gluten-Peptide
Project Leader, Department of Life Sciences
Die Rolle von NFR2 in der Melanomprogression - Einblicke in die Mechanismen von Metastasen
Project Leader, Department of Life Sciences
Etablierung der molekularen Toxikologie für rasche, frühzeitige sowie sensitive Toxizitätsbestimmungen und Biokompatibilität
Project Leader, Department of Life Sciences
Entwicklung einer Design-Pipeline für innovative Protein-Protein-Interaktionshemmer
Department of Life Sciences
MEMESA – Metastasierendes Melanom Spezifische Antikörper
Project Leader, Department of Life Sciences
AdsorbTech: Entwicklung einer neuen Technologieplattform für Peptid-basierte therapeutische Apheresesysteme
Project Leader, Department of Life Sciences
Entwicklung neuer immunregulierender Peptide und geschlechtsspezifischer organotypischer Zellmodelle für humane Sepsis
Department of Life Sciences
Entwicklung neuer Methoden zur Verbesserung von immuntherapeutischen Verfahren in der Onkologie
Department of Life Sciences
Funktionale Validierung prädiktiver Biomarker für zielgerichtete Krebstherapien
Department of Life Sciences
Etablierung innovativer, vaskulärer Äquivalente zur Entwicklung von Detektionsmodulen für Hochdurchsatz-Verfahren und zur Entwicklung von anti-entzündlichen Peptiden
Project Leader, Department of Life Sciences
Etablierung innovativer humaner Tumor-Mimetika für das Screening von bioaktiven Wirkstoffen
Department of Life Sciences
Biopharm - Isolation bioaktiver Stoffe aus Cyanobakterien
Project Leader, Department of Life Sciences
Zellbasierte Testsysteme für bioaktive Substanzen
Project Leader, Department of Life Sciences
Publications (30)
[1788]
Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717
[1005]
Kinslechner, K., Schütz, B., Pistek, M., Rapolter, P., Weitzenböck, H. P., Hundsberger, H., Mikulits, W., Grillari, J., Röhrl, C., Hengstschläger, M., Stangl, H., & Mikula, M. (2019): Loss of SR-BI Down-Regulates MITF and Suppresses Extracellular Vesicle Release in Human Melanoma. International journal of molecular sciences, 20(5): 1063.
Doi: https://doi.org/10.3390/ijms20051063
[895]
Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017): Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling. Oncotarget, 8(64): 107423–107440.
Doi: https://doi.org/10.18632/oncotarget.22475
[671]
Hundsberger, H., Önder, K., Schuller-Götzburg, P., Virok, D. P., Herzog, J., & Rid, R. (2017): Assembly and use of high-density recombinant peptide chips for large-scale ligand screening is a practical alternative to synthetic peptide libraries. BMC genomics, 18(1): 450.
Doi: https://doi.org/10.1186/s12864-017-3814-3
[900]
Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
[657]
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435
[879]
Volk, K., Breunig, S. D., Rid, R., Herzog, J., Bräuer, M., Hundsberger, H., Klein, C., Müller, N., & Önder, K. (2017): Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein. Biological chemistry, 398(1): 125-133.
Doi: https://doi.org/10.1515/hsz-2016-0185
[600]
Schütz, B., Koppensteiner, A., Schörghofer, D., Kinslechner, K., Timelthaler, G., Eferl, R., Hengstschläger, M., Missbichler, A., Hundsberger, H., & Mikula, M. (2016): Generation of metastatic melanoma specific antibodies by affinity purification. Scientific reports, 6: 37253.
Doi: https://doi.org/10.1038/srep37253
[579]
Al-Harthy, T., Zoghaib, W. M., Pflüger, M., Schöpel, M., Önder, K., Reitsammer, M., Hundsberger, H., Stoll, R., & Abdel-Jalil, R. (2016): Design, Synthesis, and Cytotoxicity of 5-Fluoro-2-methyl-6-(4-aryl-piperazin-1-yl) Benzoxazoles. Molecules, 21(10): 1290.
Doi: https://doi.org/10.3390/molecules21101290
[473]
Al-Harthy, T., Abdel-Jalil, R., Zoghaib, W., Pflüger, M., Hofmann, E., & Hundsberger, H. (2016): Design and synthesis of benzothiazole schiff bases of potential antitumor activity. Heterocycles, 92(7): 1282-1292.
Doi: https://doi.org/10.3987/COM-16-13471
[359]
Hofmann, E., Seeboeck, R., Jacobi, N., Obrist, P., Huter, S., Klein, C., Oender, K., Wiesner, C., Hundsberger, H., & Eger, A. (2016): The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer. Biomarker research, 7(4): 8.
Doi: https://doi.org/10.1186/s40364-016-0062-7
[557]
Jacobi, N., Smolinska, V., Stierschneider, A., Klein, C., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2016): Development of organotypic cancer models for the identification of individualized cancer therapies. In FH des BFI Wien (Hrsg.), Online-Tagungsband FHK Forschungsforum 2016. Wien: FFH.
[360]
Herzog, J., Rid, R., Wagner, M., Hundsberger, H., Eger, A., Bauer, J., & Önder, K. (2015): Whole-transcriptome gene expression profiling in an epidermolysis bullosa simplex Dowling-Meara model keratinocyte cell line uncovered novel, potential therapeutic targets and affected pathways. BMC research notes, 8: 785.
Doi: https://doi.org/10.1186/s13104-015-1783-7
[553]
Kreiseder, B., Holper-Schichl, Y. M., Muellauer, B., Jacobi, N., Pretsch, A., Schmid, J. A., de Martin, R., Hundsberger, H., Eger, A., & Wiesner, C. (2015): Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1. PloS one, 10(3): e0119402.
Doi: https://doi.org/10.1371/journal.pone.0119402
[535]
Pretsch, A., Nagl, M., Schwendinger, K., Kreiseder, B., Wiederstein, M., Pretsch, D., Genov, M., Hollaus, R., Zinssmeister, D., Debbab, A., Hundsberger, H., Eger, A., Proksch, P., & Wiesner, C. (2014): Antimicrobial and anti-inflammatory activities of endophytic fungi Talaromyces wortmannii extracts against acne-inducing bacteria. PloS one, 9(6): e97929.
Doi: https://doi.org/10.1371/journal.pone.0097929
[371]
Rid, R., Hundsberger, H., & Onder, K. (2014): Compound screening and transcriptional profiling in human primary keratinocytes: a brief guideline. Methods in molecular biology, 1195: 99-109.
Doi: https://doi.org/10.1007/7651_2013_50
[534]
Kapuścik, A., Hrouzek, P., Kuzma, M., Bártová, S., Novák, P., Jokela, J., Pflüger, M., Eger, A., Hundsberger, H., Kopecký, J. (2013): Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chembiochem : a European journal of chemical biology, 14(17): 2329-2337.
Doi: https://doi.org/10.1002/cbic.201300246
[533]
Rid, R., Herzog, J., Maier, R. H., Hundsberger, H., Eger, A., Hintner, H., Bauer, J. W., Onder, K. (2013): Real-time monitoring of relative peptide-protein interaction strengths in the yeast two-hybrid system. Assay and drug development technologies, 11(4): 269-275.
Doi: https://doi.org/10.1089/adt.2012.496
[842]
Rid, R., Wagner, M., Maier, C. J., Hundsberger, H., Hintner, H., Bauer, J. W., & Onder, K. (2013): Deciphering the calcitriol-induced transcriptomic response in keratinocytes: presentation of novel target genes. Journal of molecular endocrinology, 50(2): 131–149.
Doi: https://doi.org/10.1530/JME-11-0191
[1829]
Kreiseder, B., Orel, L., Bujnow, C., Buschek, S., Pflueger, M., Schuett, W., Hundsberger, H., de Martin, R., Wiesner, C. (2013): α‐Catulin downregulates E‐cadherin and promotes melanoma progression and invasion. International journal of cancer, 132(3): 521-530.
Doi: https://doi.org/10.1002/ijc.27698
[530]
Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316
[621]
Khare, V., Lyakhovich, A., Dammann, K., Lang, M., Borgmann, M., Tichy, B., Pospisilova, S., Luciani, G., Campregher, C., Evstatiev, R., Pflueger, M., Hundsberger, H., & Gasche, C. (2013): Mesalamine modulates intercellular adhesion through inhibition of p-21 activated kinase-1. Biochemical Pharmacology, 85(2): 234-244.
Doi: https://doi.org/10.1016/j.bcp.2012.10.026
[529]
Maier, C., Maier, R., Rid, R., Trost, A., Hundsberger, H., Eger, A., Hintner, H., Bauer, J., Onder, K. (2012): PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC molecular biology, 13: 18.
Doi: https://doi.org/10.1186/1471-2199-13-18
[527]
Amatschek, S., Lucas, R., Eger, A., Pflueger, M., Hundsberger, H., Knoll, C., Grosse-Kracht, S., Schuett, W., Koszik, F., Maurer, D., Wiesner, C. (2011): CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells. British journal of cancer, 104(3): 469-479.
Doi: https://doi.org/10.1038/sj.bjc.6606056
[601]
Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D., Wendel, A., Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in Bioscience, 13: 5374-86.
Doi: https://doi.org/10.2741/3087
[1828]
Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D. N., Wendel, A., & Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in bioscience : a journal and virtual library, 13: 5374–5386.
Doi: https://doi.org/10.2741/3087
[1826]
Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
[622]
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
[1823]
Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385
[1822]
Lucas, R., Hundsberger, H., Pflueger, M., Fischer, B., Morel, D., Braun, C., Wendel, A., Chakraborty, T., Schuett, W., Wiesner, C., Hamacher, J. (2007): The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug. Letters in Drug Design & Discovery, 4(5): 336-340.
Doi: https://doi.org/10.2174%2F157018007780867816
Head of Institute Biotechnology / Programme Director Medical and Pharmaceutical Biotechnology
Prof.(FH) Priv.-Doz. Mag. Dr. Harald Hundsberger
+43 2732 802 521 [email protected]
Core Competencies
Recombinant Protein Expression, Cell Culture Models, Peptide Engineering,Instrument Development

Full-time Lecturers

Hon.Prof.(FH) Mag. Alfred Siedl
Professor Department of Business
Institute Business Administration and Management
Contact
+43 2732 802[email protected]
Core Competencies (2)
Statistics, Business Mathematics
MS Office, SPSS, GeoGebra
Active in the degree programmes (4)
Betriebswirtschaft für das Gesundheitswesen
Bachelor of Arts in Business / full-time
Betriebswirtschaft für das Gesundheitswesen
Bachelor of Arts in Business / part-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Tourism and Leisure Management
Bachelor of Arts in Business / full-time
Hon.Prof.(FH) Mag. Alfred Siedl
S
Professor Department of Business
Prof.(FH) Mag. Dr. Christoph Wiesner
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 276[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
Cell and Molecular Biology
Drug Screening
Project management
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (6)
Entwicklung einer optogenetisch kontrollierbaren MSC-Zelllinie für die präzise Regulation immunmodulatorischer Faktoren
Project Leader, Department of Life Sciences
Biomarker-basierte therapeutische Prävention von Knochenmetastasen beim Mammakarzinom: die phathophysiologische Rolle der endostalen Nische
Project Leader, Department of Life Sciences
Entwicklung leistungsfähiger Diagnostikverfahren und neuer Therapieansätze in Inflammation und Sepsis
Project Leader, Department of Life Sciences
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Life Sciences
Testung von rekombinanten polyklonalen Antikörperfragmenten gegen Gluten-Peptide
Department of Life Sciences
Zellbasierte Testsysteme für bioaktive Substanzen
Department of Life Sciences
Publications (26)
[1788]
Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717
[1316]
Sarne, V., Huter, S., Braunmueller, S., Rakob, L., Jacobi, N., Kitzwögerer, M., Wiesner, C., Obrist, P., & Seeboeck, R. (2020): Promoter Methylation of Selected Genes in Non-Small-Cell Lung Cancer Patients and Cell Lines. International journal of molecular sciences, 21(13): 4595.
Doi: https://doi.org/10.3390/ijms21134595
[895]
Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017): Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling. Oncotarget, 8(64): 107423–107440.
Doi: https://doi.org/10.18632/oncotarget.22475
[900]
Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
[657]
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435
[1833]
Genov, M., Kreiseder, B., Nagl, M., Wiesner, C. et al. (2016): Tetrahydroanthraquinone Derivative (±)-4-Deoxyaustrocortilutein Induces Cell Cycle Arrest and Apoptosis in Melanoma Cells via Upregulation of p21 and p53 and Downregulation of NF-kappaB. Journal of Cancer, 7(5): 555.
Doi: https://doi:10.7150/jca.13614
[1834]
Preisitsch, M., Niedermeyer, T., Heiden, SE., Neidhardt, I., Kumpfmueller, J., Wurster, M., Harmrolfs, K., Wiesner, C., Enke, H., Mueller, R., Mundt, S. (2016): Cylindrofridins A–C, Linear Cylindrocyclophane-Related Alkylresorcinols from the Cyanobacterium Cylindrospermum stagnale. Journal of natural products, 79(1): 106-115.
Doi: https://doi.org/10.1021/acs.jnatprod.5b00768
[1832]
Preisitsch, M., Heiden, SE., Beerbaum, M., Niedermeyer, T., Schneefeld, M., Herrmann, J., Kumpfmueller, J., Thuermer, A., Neidhardt, I., Wiesner, C., Daniel, R., Mueller, R., Bange, FC., Schmieder, P., Schweder, T., Mundt, S. (2016): Effects of halide ions on the carbamidocyclophane biosynthesis in Nostoc sp. CAVN2. Marine drugs, 14(1): 21.
Doi: https://doi.org/10.3390/md14010021
[1830]
Preisitsch, M., Harmrolfs, K., Pham, HT., Heidern, SE., Fuessl, A., Wiesner, C., Pretsch, A., Switecka-Hagenbruch, M., Niedermeyer, TH., Mueller, R., Mundt, S. (2015): Anti-MRSA-acting carbamidocyclophanes H-L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. The Journal of antibiotics, 68(9): 600-600.
Doi: https://doi.org/10.1038/ja.2015.79
[553]
Kreiseder, B., Holper-Schichl, Y. M., Muellauer, B., Jacobi, N., Pretsch, A., Schmid, J. A., de Martin, R., Hundsberger, H., Eger, A., & Wiesner, C. (2015): Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1. PloS one, 10(3): e0119402.
Doi: https://doi.org/10.1371/journal.pone.0119402
[1831]
Preisitsch, M., Harmrolfs, K., Pham, H., Heiden, SE., Fuessel, A., Wiesner, C., Pretsch, A., et al. (2015): Anti-MRSA-acting carbamidocyclophanes H–L from the Vietnamese cyanobacterium Nostoc sp. CAVN2. The Journal of antibiotics, 68(3): 165-177.
Doi: https://doi.org/10.1038/ja.2014.118
[535]
Pretsch, A., Nagl, M., Schwendinger, K., Kreiseder, B., Wiederstein, M., Pretsch, D., Genov, M., Hollaus, R., Zinssmeister, D., Debbab, A., Hundsberger, H., Eger, A., Proksch, P., & Wiesner, C. (2014): Antimicrobial and anti-inflammatory activities of endophytic fungi Talaromyces wortmannii extracts against acne-inducing bacteria. PloS one, 9(6): e97929.
Doi: https://doi.org/10.1371/journal.pone.0097929
[1829]
Kreiseder, B., Orel, L., Bujnow, C., Buschek, S., Pflueger, M., Schuett, W., Hundsberger, H., de Martin, R., Wiesner, C. (2013): α‐Catulin downregulates E‐cadherin and promotes melanoma progression and invasion. International journal of cancer, 132(3): 521-530.
Doi: https://doi.org/10.1002/ijc.27698
[530]
Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316
[527]
Amatschek, S., Lucas, R., Eger, A., Pflueger, M., Hundsberger, H., Knoll, C., Grosse-Kracht, S., Schuett, W., Koszik, F., Maurer, D., Wiesner, C. (2011): CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells. British journal of cancer, 104(3): 469-479.
Doi: https://doi.org/10.1038/sj.bjc.6606056
[601]
Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D., Wendel, A., Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in Bioscience, 13: 5374-86.
Doi: https://doi.org/10.2741/3087
[1828]
Hundsberger, H., Verin, A., Wiesner, C., Pflüger, M., Dulebo, A., Schütt, W., Lasters, I., Männel, D. N., Wendel, A., & Lucas, R. (2008): TNF: a moonlighting protein at the interface between cancer and infection. Frontiers in bioscience : a journal and virtual library, 13: 5374–5386.
Doi: https://doi.org/10.2741/3087
[1826]
Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
[622]
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
[1827]
Wiesner, C., Winsauer, G., Resch, U. et al. (2008): α-Catulin, a Rho signalling component, can regulate NF-κB through binding to IKK-β, and confers resistance to apoptosis. Oncogene , 27: 2159–2169.
Doi: https://doi.org/10.1038/sj.onc.1210863
[1823]
Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385
[1825]
Winter, D., Moser, J., Kriehuber, E., Wiesner, C., Knobler, R., Trautinger, F., Bombosi, P., Stingl, G., Petzelbauer, P., Rot, A., & Maurer, D. (2007): Down-modulation of CXCR3 surface expression and function in CD8+ T cells from cutaneous T cell lymphoma patients. Journal of immunology, 179(6): 4272-4282.
Doi: https://doi.org/10.4049/jimmunol.179.6.4272
[1822]
Lucas, R., Hundsberger, H., Pflueger, M., Fischer, B., Morel, D., Braun, C., Wendel, A., Chakraborty, T., Schuett, W., Wiesner, C., Hamacher, J. (2007): The Tumor Necrosis Factor-Derived TIP Peptide: A Potential Anti-Edema Drug. Letters in Drug Design & Discovery, 4(5): 336-340.
Doi: https://doi.org/10.2174%2F157018007780867816
[1821]
Hofer-Warbinek, R., Schmid, J.A., Mayer, H., Winsauer, G., Orel, L., Mueller, B., Wiesner, C., Binder, B.R., de Martin, R. (2004): A highly conserved proapoptotic gene, IKIP, located next to the APAF1 gene locus, is regulated by p53. Cell Death & Differentiation, 11(12): 1317 - 1325.
Doi: https://doi.org/10.1038%2Fsj.cdd.4401502
[1820]
Wiesner, C., Hoeth, M., Binder, B.R., de Martin, R. (2002): A functional screening assay for the isolation of transcription factors. Nucleic Acids Research, 30(16): e80.
Doi: https://doi.org/10.1093/nar/gnf079
[1824]
Rohde, D., Wiesner, C., Graf, D. et al. (2000): Interstitial fluid pressure is increased in renal cell carcinoma xenografts. Urological Research, 28: 1-5.
Doi: https://doi.org/10.1007/s002400050001
Prof.(FH) Mag. Dr. Christoph Wiesner
W
Professor Department of Life Sciences
Dr.rer.nat.techn. Georg Sixta
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 351[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Active in the degree programmes (3)
Applied Chemistry
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Dr.rer.nat.techn. Georg Sixta
S
Professor Department of Life Sciences
Prof.(FH) DI Dominik Schild
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 501[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
Fermentation development
Biochemical Engineering
Process engineering
Active in the degree programmes (3)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Applied Chemistry
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (5)
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Project Leader, Department of Life Sciences
Synthese und industrielle Verwendung von Hydroxytyrosol
Project Leader, Department of Life Sciences
Extremophiles
Department of Life Sciences
Co-Kultivierung von Mikroorganismen
Project Leader, Department of Life Sciences
Zellbasierte Testsysteme für bioaktive Substanzen
Department of Life Sciences
Publications (2)
[1788]
Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717
[1110]
Amer, H., Mimini, V., Schild, D., Rinner, U., Bacher, H., Potthast, A., Rosenau, T. (2019): Gram-scale economical synthesis of trans-coniferyl alcohol and its corresponding thiol. Holzforschung, 74(2): 197-202.
Doi: https://doi.org/10.1515/hf-2018-0297
Prof.(FH) DI Dominik Schild
S
Professor Department of Life Sciences
Prof.(FH) Mag. Dana Mezricky
Professorin Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 322[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
GMP/GLP
Molecular Biology
Proteinchemistry / Immunology/ Biochemical Analytics Methods
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (3)
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Life Sciences
Extremophiles
Department of Life Sciences
Co-Kultivierung von Mikroorganismen
Department of Life Sciences
Publications (4)
[1329]
Čížková, M., Mezricky, P., Mezricky, D., Rucki, M., Zachleder, V., Vítová, M. (2020): Bioaccumulation of Rare Earth Elements from Waste Luminophores in the Red Algae, Galdieria phlegrea. Waste Biomass Valor.
Doi: https://doi.org/10.1007/s12649-020-01182-3
[1328]
Rezanka, T., Rezanka, M., Mezricky, D., Vítova, M. (2020): Lipidomic analysis of diatoms cultivated with silica nanoparticles. Phytochemistry, 177: 112452.
Doi: https://doi.org/10.1016/j.phytochem.2020.112452
[1020]
Čížková, M., Mezricky, D., Rucki, M., Tóth, T. M., Náhlík, V., Lanta, V., Bišová, K., Zachleder, V., & Vítová, M. (2019): Bio-mining of Lanthanides from Red Mud by Green Microalgae. Molecules , 24(7): 1356.
Doi: https://doi.org/10.3390/molecules24071356
[352]
Řezanka, T., Kaineder, K., Mezricky, D., Řezanka, M., Bišová, K., Zachleder, V., & Vítová, M. (2016): The effect of lanthanides on photosynthesis, growth, and chlorophyll profile of the green alga Desmodesmus quadricauda. Photosynthesis Research, 130(1-3): 335-346.
Doi: https://doi.org/10.1007/s11120-016-0263-9
Prof.(FH) Mag. Dana Mezricky
M
Professorin Department of Life Sciences
DI (FH) Anita Koppensteiner
Research Assistant / Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 527[email protected]
Location
IMC Campus Krems
IMC Campus Trakt D
Core Competencies (3)
Protein Production, Purification and Analysis
Cell-Based Assays/Microscopy
Biochemical Test Methods and Analysis
Active in the degree programmes (3)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Applied Chemistry
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (6)
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Life Sciences
Die Rolle von NFR2 in der Melanomprogression - Einblicke in die Mechanismen von Metastasen
Department of Life Sciences
Extremophiles
Department of Life Sciences
MEMESA – Metastasierendes Melanom Spezifische Antikörper
Department of Life Sciences
AdsorbTech: Entwicklung einer neuen Technologieplattform für Peptid-basierte therapeutische Apheresesysteme
Department of Life Sciences
Etablierung innovativer, vaskulärer Äquivalente zur Entwicklung von Detektionsmodulen für Hochdurchsatz-Verfahren und zur Entwicklung von anti-entzündlichen Peptiden
Department of Life Sciences
Publications (3)
[657]
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435
[600]
Schütz, B., Koppensteiner, A., Schörghofer, D., Kinslechner, K., Timelthaler, G., Eferl, R., Hengstschläger, M., Missbichler, A., Hundsberger, H., & Mikula, M. (2016): Generation of metastatic melanoma specific antibodies by affinity purification. Scientific reports, 6: 37253.
Doi: https://doi.org/10.1038/srep37253
[530]
Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316
DI (FH) Anita Koppensteiner
K
Research Assistant / Department of Life Sciences
Prof.(FH) Priv.Doz. Dr. Reinhard Klein
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 883[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (2)
Virology
Molecular biology
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (3)
In-Vivo-RNA Interferenzstrategien gegen Adenoviren
Project Leader, Department of Life Sciences
Virale und fungale Infektionen
Project Leader, Department of Life Sciences
RNA Interferenz als Methode zur Inhibierung von Virusinfektionen
Project Leader, Department of Life Sciences
Publications (25)
[1639]
Selb, R., Derntl, C., Klein, R., Alte, B., Hofbauer, C., Kaufmann, M., Beraha, J., Schöner, L., & Witte, A. (2017): The Viral Gene ORF79 Encodes a Repressor Regulating Induction of the Lytic Life Cycle in the Haloalkaliphilic Virus ϕCh1. Journal of virology, 91(9): e00206-17.
Doi: https://doi.org/10.1128/JVI.00206-17
[353]
Derntl, C., Selb, R., Klein, R., Alte, B., & Witte, A. (2015): Genomic manipulations in alkaliphilic haloarchaea demonstrated by a gene disruption in Natrialba magadii. FEMS microbiology letters, 362(21): fnv179.
Doi: https://doi.org/10.1093/femsle/fnv179
[1648]
Derntl, C., Selb, R., Klein, R., Alte, B., & Witte, A. (2015): Genomic manipulations in alkaliphilic haloarchaea demonstrated by a gene disruption in Natrialba magadii. FEMS microbiology letters, 362(21): fnv179.
Doi: https://doi.org/10.1093/femsle/fnv179
[355]
Bellutti, F., Kauer, M., Kneidinger, D., Lion, T., & Klein, R. (2015): Identification of RISC-associated adenoviral microRNAs, a subset of their direct targets, and global changes in the targetome upon lytic adenovirus 5 infection. Journal of virology, 89(3): 1608–1627.
Doi: https://doi.org/10.1128/JVI.02336-14
[1649]
Bellutti, F., Kauer, M., Kneidinger, D., Lion, T., & Klein, R. (2015): Identification of RISC-associated adenoviral microRNAs, a subset of their direct targets, and global changes in the targetome upon lytic adenovirus 5 infection. Journal of virology, 89(3): 1608–1627.
Doi: https://doi.org/10.1128/JVI.02336-14
[1650]
Ibrišimović, M., Lion, T., & Klein, R. (2013): Combinatorial targeting of 2 different steps in adenoviral DNA replication by herpes simplex virus thymidine kinase and artificial microRNA expression for the inhibition of virus multiplication in the presence of ganciclovir. BMC biotechnology, 13(1): 54.
Doi: https://doi.org/10.1186/1472-6750-13-54
[1652]
Mayrhofer-Iro, M., Ladurner, A., Meissner, C., Derntl, C., Reiter, M., Haider, F., Dimmel, K., Rössler, N., Klein, R., Baranyi, U., Scholz, H., & Witte, A. (2013): Utilization of virus φCh1 elements to establish a shuttle vector system for Halo(alkali)philic Archaea via transformation of Natrialba magadii. Applied and environmental microbiology, 79(8): 2741–2748.
Doi: https://doi.org/10.1128/AEM.03287-12
[1651]
Ibrišimović, M., Kneidinger, D., Lion, T., & Klein, R. (2013): An adenoviral vector-based expression and delivery system for the inhibition of wild-type adenovirus replication by artificial microRNAs. Antiviral research, 97(1): 10–23.
Doi: https://doi.org/10.1016/j.antiviral.2012.10.008
[1653]
Kneidinger, D., Ibrišimović, M., Lion, T., & Klein, R. (2012): Inhibition of adenovirus multiplication by short interfering RNAs directly or indirectly targeting the viral DNA replication machinery. Antiviral research, 94(3): 195–207.
Doi: https://doi.org/10.1016/j.antiviral.2012.03.011
[1654]
Ibrišimović, M., Nagl, U., Kneidinger, D., Rauch, M., Lion, T., & Klein, R. (2012): Targeted expression of herpes simplex virus thymidine kinase in adenovirus-infected cells reduces virus titers upon treatment with ganciclovir in vitro. The journal of gene medicine, 114(1): 3–19.
Doi: https://doi.org/10.1002/jgm.1638
[1655]
Klein, R., Rössler, N., Iro, M., Scholz, H., & Witte, A. (2012): Haloarchaeal myovirus φCh1 harbours a phase variation system for the production of protein variants with distinct cell surface adhesion specificities. Molecular microbiology, 83(1): 137–150.
Doi: https://doi.org/10.1111/j.1365-2958.2011.07921.x
[1656]
Klein, R., Ruttkowski, B., Schwab, S., Peterbauer, T., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2008): Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo. Journal of biomedicine & biotechnology, 2008(683505 ): 10.
Doi: https://doi.org/10.1155/2008/683505
[1657]
Agu, C. A., Klein, R., Lengler, J., Schilcher, F., Gregor, W., Peterbauer, T., Bläsi, U., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2007): Bacteriophage-encoded toxins: the lambda-holin protein causes caspase-independent non-apoptotic cell death of eukaryotic cells. Cellular microbiology, 9(7): 1753–1765.
Doi: https://doi.org/10.1111/j.1462-5822.2007.00911.x
[1658]
Iro, M., Klein, R., Gálos, B., Baranyi, U., Rössler, N., & Witte, A. (2007): The lysogenic region of virus phiCh1: identification of a repressor-operator system and determination of its activity in halophilic Archaea. xtremophiles : life under extreme conditions, 11(2): 383–396.
Doi: https://doi.org/10.1007/s00792-006-0040-3
[1660]
Klein, R., Ruttkowski, B., Knapp, E., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2006): WPRE-mediated enhancement of gene expression is promoter and cell line specific. Gene, 372: 153–161.
Doi: https://doi.org/10.1016/j.gene.2005.12.018
[1661]
Hand, N. J., Klein, R., Laskewitz, A., & Pohlschröder, M. (2006): Archaeal and bacterial SecD and SecF homologs exhibit striking structural and functional conservation. Journal of bacteriology,, 188(4): 1251–1259.
Doi: https://doi.org/10.1128/JB.188.4.1251-1259.2006
[1659]
Agu, C. A., Klein, R., Schwab, S., König-Schuster, M., Kodajova, P., Ausserlechner, M., Binishofer, B., Bläsi, U., Salmons, B., Günzburg, W. H., & Hohenadl, C. (2006): The cytotoxic activity of the bacteriophage lambda-holin protein reduces tumour growth rates in mammary cancer cell xenograft models. The journal of gene medicine, 8(2): 229–241.
Doi: https://doi.org/10.1002/jgm.833
[1662]
Mangold, M., Siller, M., Roppenser, B., Vlaminckx, B. J., Penfound, T. A., Klein, R., Novak, R., Novick, R. P., & Charpentier, E. (2004): Synthesis of group A streptococcal virulence factors is controlled by a regulatory RNA molecule. Molecular microbiology, 53(5): 1515–1527.
Doi: https://doi.org/10.1111/j.1365-2958.2004.04222.x
[1663]
Rössler, N., Klein, R., Scholz, H., & Witte, A. (2004): Inversion within the genome of the haloalkaliphilic virus phiCh1 results in differential expression of structural proteins. Molecular microbiology, 52(2): 413–426.
Doi: https://doi.org/10.1111/j.1365-2958.2003.03983.x
[1664]
Klein, R., Baranyi, U., Rössler, N., Greineder, B., Scholz, H., & Witte, A. (2002): Natrialba magadii virus fCh: First complete nucleotide sequence and functional organization of a virus infecting an extreme haloalkaliphilic archaeon. Molecular microbiology, 45(3): 851–863.
Doi: https://doi.org/10.1046/j.1365-2958.2002.03064.x
[1666]
Klein, R., Greineder, B., Baranyi, U., & Witte, A. (2000): The structural protein E of the archaeal virus phiCh1: evidence for processing in Natrialba magadii during virus maturation. Virology, 276(2): 376–387.
Doi: https://doi.org/10.1006/viro.2000.0565
[1665]
Baranyi, U., Klein, R., Lubitz, W., Krüger, D. H., & Witte, A. (2000): The archaeal halophilic virus-encoded Dam-like methyltransferase M. phiCh1-I methylates adenine residues and complements dam mutants in the low salt environment of Escherichia coli. Molecular microbiology, 35(5): 1168–1179.
Doi: https://doi.org/10.1046/j.1365-2958.2000.01786.x
[1667]
Katinger, A., Lubitz, W., Szostak, M. P., Stadler, M., Klein, R., Indra, A., Huter, V., & Hensel, A. (1999): Pigs aerogenously immunized with genetically inactivated (ghosts) or irradiated Actinobacillus pleuropneumoniae are protected against a homologous aerosol challenge despite differing in pulmonary cellular and antibody responses. Journal of biotechnology, 73(2-3): 251–260.
Doi: https://doi.org/10.1016/s0168-1656(99)00143-1
[1668]
Witte, A., Baranyi, U., Klein, R., Sulzner, M., Luo, C., Wanner, G., Krüger, D. H., & Lubitz, W. (1997): Characterization of Natronobacterium magadii phage phi Ch1, a unique archaeal phage containing DNA and RNA. Molecular microbiology, 23(3): 603–616.
Doi: https://doi.org/10.1046/j.1365-2958.1997.d01-1879.x
[1669]
Szostak, M. P., Hensel, A., Eko, F. O., Klein, R., Auer, T., Mader, H., Haslberger, A., Bunka, S., Wanner, G., & Lubitz, W. (1996): Bacterial ghosts: non-living candidate vaccines. Journal of biotechnology, 44(1-3): 161–170.
Doi: https://doi.org/10.1016/0168-1656(95)00123-9
Prof.(FH) Priv.Doz. Dr. Reinhard Klein
K
Professor Department of Life Sciences
Prof.(FH) Dr. Christian Klein
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 522[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
Computer-Aided Drug Design
Biochemical Systems Theory
Molecular Modeling and Chemoinformatics
Active in the degree programmes (3)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Applied Chemistry
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (4)
Entwicklung von therapeutischen Peptiden für Krebs- und regenerative Medizin
Department of Life Sciences
Entwicklung einer Design-Pipeline für innovative Protein-Protein-Interaktionshemmer
Project Leader, Department of Life Sciences
Entwicklung neuer immunregulierender Peptide und geschlechtsspezifischer organotypischer Zellmodelle für humane Sepsis
Department of Life Sciences
Funktionale Validierung prädiktiver Biomarker für zielgerichtete Krebstherapien
Department of Life Sciences
Publications (30)
[1788]
Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717
[1315]
Ablinger, C., Geisler, S. M., Stanika, R. I., Klein, C. T., & Obermair, G. J. (2020): Neuronal α2δ proteins and brain disorders. Pflugers Archiv : European journal of physiology, 472(7): 845-863.
Doi: https://doi.org/10.1007/s00424-020-02420-2
[900]
Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
[657]
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435
[879]
Volk, K., Breunig, S. D., Rid, R., Herzog, J., Bräuer, M., Hundsberger, H., Klein, C., Müller, N., & Önder, K. (2017): Structural analysis and interaction studies of acyl-carrier protein (acpP) of Staphylococcus aureus, an extraordinarily thermally stable protein. Biological chemistry, 398(1): 125-133.
Doi: https://doi.org/10.1515/hsz-2016-0185
[359]
Hofmann, E., Seeboeck, R., Jacobi, N., Obrist, P., Huter, S., Klein, C., Oender, K., Wiesner, C., Hundsberger, H., & Eger, A. (2016): The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer. Biomarker research, 7(4): 8.
Doi: https://doi.org/10.1186/s40364-016-0062-7
[557]
Jacobi, N., Smolinska, V., Stierschneider, A., Klein, C., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2016): Development of organotypic cancer models for the identification of individualized cancer therapies. In FH des BFI Wien (Hrsg.), Online-Tagungsband FHK Forschungsforum 2016. Wien: FFH.
[1819]
Solca, F., Dahl, G., Zoephel, A., Bader, G., Sanderson, M., Klein, C.T., Kraemer, O., Himmelsbach, F., Haaksma, E., Adolf, G. R. (2012): Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker. Journal of Pharmacology and Experimental Therapeutics, 343(2): 342-350.
Doi: https://doi.org/10.1124/jpet.112.197756
[1818]
Klein, C.T., Kaiser, D., Ecker, G. (2004): 3D Topolgical Distance-Based Descriptors for Use in QSAR and Diversity Analysis. Journal of Chemical Information and Computer Sciences, 44(1): 200-209.
Doi: https://doi.org/10.1021/ci0256236
[1817]
Klein, C.T., Kaiser, D., Kopp, S., Chiba, P., Ecker, G. (2002): Similarity-Based SAR as Tool for Early ADME Profiling. Journal of Computer-Aided Molecular Design, 16: 785-793.
Doi: https://doi.org/10.1023/A:1023828527638
[1816]
Klein, C.T., Kaiblinger, N., Wolschann, P. (2002): Internally Defined Distances in 3D-Quantitative Structure-Activity Relationships. Journal of Computer-Aided Molecular Design, 16: 79-93.
Doi: https://doi.org/10.1023/A:1016308417830
[1812]
Mayer, B., Klein, C.T. (2000): Influence of Solvation on the Helix Forming Tendency of Nonpolar Amino Acids. Journal of Molecular Structure: THEOCHEM, 532(1-3): 213-226.
Doi: https://doi.org/10.1016/S0166-1280(00)00559-5
[1815]
Buchbauer, G., Klein, C.T., Wailzer, B., Wolschann, P. (2000): Threshold-Based Structure-Activity Relationships of Pyrazines with Bell Pepper Flavor. Journal of Agricultural and Food Chemistry, 48(9): 4273-4278.
Doi: https://doi.org/10.1021/jf000192h
[1809]
Klein, C.T., Polheim, D., Viernstein, H., Wolschann, P. (2000): A Method for Estimation of the Free Energies of Complexation between ß-Cyclodextrin and Guest Molecules. Journal of Inclusion Phenomena, 36(4): 409-423.
Doi: https://doi.org/10.1023/A:1008063412529
[1813]
Klein, C.T., Pircher, H., Wailzer, B., Buchbauer, G., Wolschann, P. (2000): Quantitative Structure-Property Study on Pyrazines with Bell Peper Flavor. Scientific Pharmaceutica, 68(1): 41-56.
Doi: https://doi.org/10.3797/scipharm.aut-00-04
[1811]
Klein, C.T., Lawtrakul, L., Hannongbua, S., Wolschann, P. (2000): Accessible Charges as Sensitive Descriptors in Structure-Activity Relationships. A Study on HEPT-based HIV-1 RT Inhibitors. Scientific Pharmaceutica, 68(1): 25-40.
Doi: https://doi.org/10.3797/scipharm.aut-00-03
[1814]
Klein, C.T., Viernstein, H., Wolschann, P. (2000): Free Energy Prediction of Complexation between ß-Cyclodextrin and Guest Molecules: External Predictivity of MR and PLS Models. Scientific Pharamaceutica, 68(1): 15-24.
Doi: https://doi.org/10.3797/scipharm.aut-00-02
[1810]
Klein, C.T., Polheim, D., Viernstein, H., Wolschann, P. (2000): Predicting the Free Energies of Complexation between Cyclodextrins and Guest Molecules: Linear versus Nonlinear Models. Pharamaceutical Research, 17: 358-365.
Doi: https://doi.org/10.1023/A:1007565409407
[1808]
Mayer, B., Klein, C.T., Köhler, G. (1999): Selective Assembly of Cyclodextrins on Poly(ethylene oxide) Poly(propylene oxide) Copolymers. Journal of Computer-Aided Molecular Design, 13: 373-383.
Doi: https://doi.org/10.1023/A:1008095501870
[1807]
Klein, C.T., Mayer, B. (1999): Sources for Switches and Structure Formation in Metabolic Pathways. Biosystems, 51(1): 41-52.
Doi: https://doi.org/10.1016/S0303-2647(99)00012-X
[1805]
Klein, C.T., Mayer, B., Köhler, G., Wolschann, P. (1998): Systematic Stepsize Variation: An Efficient Method for Searching the Conformational Space of Polypeptides. Journal of Computational Chemistry, 19(13): 1470-1481.
Doi: https://doi.org/10.1002/(SICI)1096-987X(199810)19:13<1470::AID-JCC4>3.0.CO;2-N
[1806]
Klein, C.T. (1998): Hysteresis-Driven Pattern Formation in Biochemical Networks. Journal of Theoretical Biology, 194(2): 263-274.
Doi: https://doi.org/10.1006/jtbi.1998.0757
[1804]
Mayer, B., Marconi, G., Klein, C.T., Köhler, G., Wolschann, P. (1997): Structural Analysis of Host–Guest Systems. Methyl-substituted Phenols in beta;-Cyclodextrin. Journal of inclusion phenomena and molecular recognition in chemistry, 29: 79-93.
Doi: https://doi.org/10.1023/A:1007920606983
[1802]
Klein, C.T., Mayer, B. (1997): A Model for Pattern Formation in Gap-Junction Coupled Cells. Journal of Theoretical Biology, 186(1): 107-115.
Doi: https://doi.org/10.1006/jtbi.1996.0337
[1803]
Grabner, G., Monti, S., Marconi, G., Mayer, B., Klein, C.T., Köhler, G. (1997): Spectroscopic and Photochemical Study of Inclusion Complexes of Dimethoxybenzenes with Cyclodextrins. The Journal of Physical Chemistry , 100(51): 20068-20075.
Doi: https://doi.org/10.1021/jp962231r
[1799]
Marconi, G., Mayer, B., Klein, C.T., Köhler, G. (1996): The structure of higher order C60-fullerene-γ-cyclodextrin complexes. Chemical Physics Letters, 260(5-6): 589-594.
Doi: https://doi.org/10.1016/0009-2614(96)00915-3
[1801]
Köhler, G., Grabner, G., Klein, C.T., Marconi, G., Mayer, B., Monti, S., Rechthaler, K., Rotkiewicz, K., Viernstein, H., Wolschann, P. (1996): Structure and spectroscopic Properties in Cyclodextrin Inclusion Complexes. In Szejtli, J., Szente, L. (Hrsg.), Proceedings of the Eighth International Symposium on Cyclodextrins (215-220). Budapest, Hungary: Springer, Dordrecht.
Doi: https://doi.org/10.1007/978-94-011-5448-2_46
[1800]
Klein, C.T., Mayer, B., Köhler, G., Wolschann, P. (1996): Influence of solvation on helix formation of poly-alanine studied by multiple annealing simulations. Journal of Molecular Structure: THEOCHEM, 372(1): 33-43.
Doi: https://doi.org/10.1016/S0166-1280(96)04745-8
[1796]
Klein, C. T., & Seelig, F. F. (1995): Turing structures in a system with regulated gap-junctions. Bio Systems, 35(1): 15–23.
Doi: https://doi.org/10.1016/0303-2647(94)01478-p
[1797]
Klein, C.T., Mayer, B., Köhler, G., Mraz, K., Reiter, S., Viernstein, H., Wolschann, P. (1995): Solubility and Molecular Modeling of Triflumizole-ß-cyclodextrin Inclusion Complexes. Journal of inclusion phenomena and molecular recognition in chemistry, 22: 15–32.
Doi: https://doi.org/10.1007/BF00706495
Prof.(FH) Dr. Christian Klein
K
Professor Department of Life Sciences
Prof.(FH) DI Bernhard Klausgraber
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 348[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
Inorganic and Organic Chemistry
Microbiology
Fermentation Development and Optimization
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (5)
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Life Sciences
Synthese und industrielle Verwendung von Hydroxytyrosol
Department of Life Sciences
Extremophiles
Project Leader, Department of Life Sciences
Co-Kultivierung von Mikroorganismen
Department of Life Sciences
Etablierung innovativer humaner Tumor-Mimetika für das Screening von bioaktiven Wirkstoffen
Department of Life Sciences
Prof.(FH) DI Bernhard Klausgraber
K
Professor Department of Life Sciences
Prof.(FH) Dr. Barbara Entler
Professor Department of Life Sciences
Institute Biotechnology
Contact
+43 2732 802 361[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
Microbiology
Microbial Monitoring
Genetic Engineering
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Projects (1)
Nachhaltiges biologisches Recycling von umweltbedenklichen Stoffen (Rare Earth Elements) aus Elektronikabfall und Abwässern
Department of Life Sciences
Publications (4)
[675]
Moritz, B., Locatelli, V., Niess, M., Bathke, A., Kiessig, S., Entler, B., Finkler, C., Wegele, H., & Stracke, J. (2017): Optimization of capillary zone electrophoresis for charge heterogeneity testing of biopharmaceuticals using enhanced method development principles. Electrophoresis, 38(24): 3136–3146.
Doi: https://doi.org/10.1002/elps.201700145
[1826]
Wiesner, C., Pflueger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schuett, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene interdisziplinar, 3(1).
[622]
Wiesner, C., Pflüger, M., Kopecky, J., Stys, D., Entler, B., Lucas, R., Hundsberger, H., Schütt, W. (2008): Implementation of ECIS technology for the characterization of potential therapeutic drugs that promote wound-healing. GMS Krankenhaushygiene Interdisziplinär, 3(1): Doc05.
[1823]
Wiesner, C., Lucas, R., Pflueger, M., Kleber, C., Kopecky, J., Stys, D., Entler, B., Hundsberger, H., Atzler, J., Hrouzek, P., Lukesova, A., Schuett, W., (2007): Endothelial Cell-Based Methods for the Detection of Cyanobacterial Anti- Inflammatory and Wound-Healing Promoting Metabolites. Drug Metabolism Letters, 1(4): 254-260.
Doi: https://doi.org/10.2174/187231207783221385
Prof.(FH) Dr. Barbara Entler
E
Professor Department of Life Sciences
Prof.(FH) Priv. Doz. Mag. Dr. Andreas Eger
Head of Research Institute Krems Bioanalytics / Professor Department of Life Sciences
Institute Krems Bioanalytics
Contact
+43 2732 802 369[email protected]
Location
IMC Campus Krems
IMC Campus Trakt G
Core Competencies (3)
Drug Discovery
Organotypic Disease Models
Bioanalytics and Biomarker
Active in the degree programmes (2)
Medical and Pharmaceutical Biotechnology
Master of Science in Engineering / full-time
Medical and Pharmaceutical Biotechnology
Bachelor of Science in Engineering / full-time
Projects (10)
Stoffwechsel-Plasma-Analyse bei metabolischem Syndrom und Tumorkachexie
Project Leader, Department of Life Sciences
DNA Methylierung im Lungenkrebs und ihre geschlechtsspezifische Auswirkung auf die Effizienz epigenetischer Therapien
Department of Life Sciences
Entwicklung von therapeutischen Peptiden für Krebs- und regenerative Medizin
Project Leader, Department of Life Sciences
Etablierung der molekularen Toxikologie für rasche, frühzeitige sowie sensitive Toxizitätsbestimmungen und Biokompatibilität
Department of Life Sciences
Entwicklung komplexer extrakorporaler Karzinommodelle für die Identifikation personalisierter Krebstherapien
Project Leader, Department of Life Sciences
AdsorbTech: Entwicklung einer neuen Technologieplattform für Peptid-basierte therapeutische Apheresesysteme
Department of Life Sciences
Entwicklung neuer immunregulierender Peptide und geschlechtsspezifischer organotypischer Zellmodelle für humane Sepsis
Department of Life Sciences
Entwicklung neuer Methoden zur Verbesserung von immuntherapeutischen Verfahren in der Onkologie
Project Leader, Department of Life Sciences
Funktionale Validierung prädiktiver Biomarker für zielgerichtete Krebstherapien
Project Leader, Department of Life Sciences
Etablierung innovativer humaner Tumor-Mimetika für das Screening von bioaktiven Wirkstoffen
Project Leader, Department of Life Sciences
Publications (35)
[1788]
Hundsberger, H., Stierschneider, A., Sarne, V., Ripper, D., Schimon, J., Weitzenböck, H. P., Schild, D., Jacobi, N., Eger, A., Atzler, J., Klein, C. T., & Wiesner, C. (2021): Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. Molecules (Basel, Switzerland), 26(3): 717.
Doi: https://doi.org/10.3390/molecules26030717
[895]
Jacobi, N., Seeboeck, R., Hofmann, E., Schweiger, H., Smolinska, V., Mohr, T., Boyer, A., Sommergruber, W., Lechner, P., Pichler-Huebschmann, C., Önder, K., Hundsberger, H., Wiesner, C., & Eger, A. (2017): Organotypic three-dimensional cancer cell cultures mirror drug responses in vivo: lessons learned from the inhibition of EGFR signaling. Oncotarget, 8(64): 107423–107440.
Doi: https://doi.org/10.18632/oncotarget.22475
[900]
Jacobi, N., Smolinska, V., Seeboeck, R., Stierschneider, A., Klein, C., Hofmann, E., Wiesner, C., Mohr, T., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2017): 3D Anti-Cancer drug discovery models: A promising approach for precision medicine. In IMC Fachhochschule Krems GmbH (Hrsg.), Online-Tagungsband FHK Forschungsforum 2017. Krems: FFH.
[896]
Jacobi, N., Seeboeck, R., Hofmann, E., & Eger, A. (2017): ErbB Family Signalling: A Paradigm for Oncogene Addiction and Personalized Oncology. Cancers, 9(4): 33.
Doi: https://doi.org/10.3390/cancers9040033
[657]
Hundsberger, H., Koppensteiner, A., Hofmann, E., Ripper, D., Pflüger, M., Stadlmann, V., Klein, C. T., Kreiseder, B., Katzlinger, M., Eger, A., Forster, F., Missbichler, A., & Wiesner, C. (2017): A Screening Approach for Identifying Gliadin Neutralizing Antibodies on Epithelial Intestinal Caco-2 Cells. SLAS discovery : advancing life sciences R & D, 22(8): 1035–1043.
Doi: https://doi.org/10.1177/2472555217697435
[359]
Hofmann, E., Seeboeck, R., Jacobi, N., Obrist, P., Huter, S., Klein, C., Oender, K., Wiesner, C., Hundsberger, H., & Eger, A. (2016): The combinatorial approach of laser-captured microdissection and reverse transcription quantitative polymerase chain reaction accurately determines HER2 status in breast cancer. Biomarker research, 7(4): 8.
Doi: https://doi.org/10.1186/s40364-016-0062-7
[557]
Jacobi, N., Smolinska, V., Stierschneider, A., Klein, C., Oender, K., Lechner, P., Kaiser, H., Hundsberger, H., Eger, A. (2016): Development of organotypic cancer models for the identification of individualized cancer therapies. In FH des BFI Wien (Hrsg.), Online-Tagungsband FHK Forschungsforum 2016. Wien: FFH.
[360]
Herzog, J., Rid, R., Wagner, M., Hundsberger, H., Eger, A., Bauer, J., & Önder, K. (2015): Whole-transcriptome gene expression profiling in an epidermolysis bullosa simplex Dowling-Meara model keratinocyte cell line uncovered novel, potential therapeutic targets and affected pathways. BMC research notes, 8: 785.
Doi: https://doi.org/10.1186/s13104-015-1783-7
[553]
Kreiseder, B., Holper-Schichl, Y. M., Muellauer, B., Jacobi, N., Pretsch, A., Schmid, J. A., de Martin, R., Hundsberger, H., Eger, A., & Wiesner, C. (2015): Alpha-catulin contributes to drug-resistance of melanoma by activating NF-κB and AP-1. PloS one, 10(3): e0119402.
Doi: https://doi.org/10.1371/journal.pone.0119402
[536]
Bakiri, L., Macho-Maschler, S., Custic, I., Niemiec, J., Guío-Carrión, A., Hasenfuss, S. C., Eger, A., Müller, M., Beug, H., & Wagner, E. F. (2015): Fra-1/AP-1 induces EMT in mammary epithelial cells by modulating Zeb1/2 and TGFβ expression. Cell death and differentiation, 22(2): 336–350.
Doi: https://doi.org/10.1038/cdd.2014.157
[498]
Spilka, R., Ernst, C., Bergler, H., Rainer, J., Flechsig, S., Vogetseder, A., Lederer, E., Benesch, M., Brunner, A., Geley, S., Eger, A., Bachmann, F., Doppler, W., Obrist, P., & Haybaeck, J. (2014): eIF3a is over-expressed in urinary bladder cancer and influences its phenotype independent of translation initiation. Cellular oncology (Dordrecht), 37(4): 253–267.
Doi: https://doi.org/10.1007/s13402-014-0181-9
[535]
Pretsch, A., Nagl, M., Schwendinger, K., Kreiseder, B., Wiederstein, M., Pretsch, D., Genov, M., Hollaus, R., Zinssmeister, D., Debbab, A., Hundsberger, H., Eger, A., Proksch, P., & Wiesner, C. (2014): Antimicrobial and anti-inflammatory activities of endophytic fungi Talaromyces wortmannii extracts against acne-inducing bacteria. PloS one, 9(6): e97929.
Doi: https://doi.org/10.1371/journal.pone.0097929
[534]
Kapuścik, A., Hrouzek, P., Kuzma, M., Bártová, S., Novák, P., Jokela, J., Pflüger, M., Eger, A., Hundsberger, H., Kopecký, J. (2013): Novel Aeruginosin-865 from Nostoc sp. as a potent anti-inflammatory agent. Chembiochem : a European journal of chemical biology, 14(17): 2329-2337.
Doi: https://doi.org/10.1002/cbic.201300246
[533]
Rid, R., Herzog, J., Maier, R. H., Hundsberger, H., Eger, A., Hintner, H., Bauer, J. W., Onder, K. (2013): Real-time monitoring of relative peptide-protein interaction strengths in the yeast two-hybrid system. Assay and drug development technologies, 11(4): 269-275.
Doi: https://doi.org/10.1089/adt.2012.496
[530]
Pflüger, M., Kapuscik, A., Lucas, R., Koppensteiner, A., Katzlinger, M., Jokela, J., Eger, A., Jacobi, N., Wiesner, C., Hofmann, E., Onder, K., Kopecky, J., Schütt, W., Hundsberger, H. (2013): A combined impedance and AlphaLISA-based approach to identify anti-inflammatory and barrier-protective compounds in human endothelium. Journal of biomolecular screening, 18(1): 67-74.
Doi: https://doi.org/10.1177/1087057112458316
[532]
Imhof, M., Karas, I., Gomez, I., Eger, A., & Imhof, M. (2013): Interaction of tumor cells with the immune system: implications for dendritic cell therapy and cancer progression. Drug discovery today, 18(1-2): 35-42.
Doi: https://doi.org/10.1016/j.drudis.2012.07.010
[529]
Maier, C., Maier, R., Rid, R., Trost, A., Hundsberger, H., Eger, A., Hintner, H., Bauer, J., Onder, K. (2012): PIM-1 kinase interacts with the DNA binding domain of the vitamin D receptor: a further kinase implicated in 1,25-(OH)2D3 signaling. BMC molecular biology, 13: 18.
Doi: https://doi.org/10.1186/1471-2199-13-18
[528]
Vonach, C., Viola, K., Giessrigl, B., Huttary, N., Raab, I., Kalt, R., Krieger, S., Vo, T. P., Madlener, S., Bauer, S., Marian, B., Hämmerle, M., Kretschy, N., Teichmann, M., Hantusch, B., Stary, S., Unger, C., Seelinger, M., Eger, A., Mader, R., Jäger, W., Schmidt, W., Grusch, M., Dolznig, H., Mikulits, W., Krupitza, G. (2011): NF-κB mediates the 12(S)-HETE-induced endothelial to mesenchymal transition of lymphendothelial cells during the intravasation of breast carcinoma cells. British journal of cancer, 105(2): 263-271.
Doi: https://doi.org/10.1038/bjc.2011.194
[527]
Amatschek, S., Lucas, R., Eger, A., Pflueger, M., Hundsberger, H., Knoll, C., Grosse-Kracht, S., Schuett, W., Koszik, F., Maurer, D., Wiesner, C. (2011): CXCL9 induces chemotaxis, chemorepulsion and endothelial barrier disruption through CXCR3-mediated activation of melanoma cells. British journal of cancer, 104(3): 469-479.
Doi: https://doi.org/10.1038/sj.bjc.6606056
[526]
Spaderna, S., Schmalhofer, O., Wahlbuhl, M., Dimmler, A., Bauer, K., Sultan, A., Hlubek, F., Jung, A., Strand, D., Eger, A., Kirchner, T., Behrens, J., & Brabletz, T. (2008): The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer research, 68(2): 537–544.
Doi: https://doi.org/10.1158/0008-5472.CAN-07-5682
[525]
Mikula M., Lahsnig C., Fischer A. N. M., Proell V., Huber H, Fuchs E., Eger A., Beug H. and Mikulits W. (2007): Epithelial plasticity of hepatocytes during liver tumor progression. Stem cells and their potential for clinical application. NATO Science for Peace and Security. Series/NATO Science Foundation. Springer Netherland, Edition 1.
[523]
Aigner, K., Dampier, B., Descovich, L., Mikula, M., Sultan, A., Schreiber, M., Mikulits, W., Brabletz, T., Strand, D., Obrist, P., Sommergruber, W., Schweifer, N., Wernitznig, A., Beug, H., Foisner, R., & Eger, A. (2007): The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene, 26(49): 6979–6988.
Doi: https://doi.org/10.1038/sj.onc.1210508
[524]
Aigner, K., Descovich, L., Mikula, M., Sultan, A., Dampier, B., Bonné, S., van Roy, F., Mikulits, W., Schreiber, M., Brabletz, T., Sommergruber, W., Schweifer, N., Wernitznig, A., Beug, H., Foisner, R., & Eger, A. (2007): The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS letters, 581(8): 1617-24.
Doi: https://doi.org/10.1016/j.febslet.2007.03.026
[507]
Pacher, M., Seewald, M. J., Mikula, M., Oehler, S., Mogg, M., Vinatzer, U., Eger, A., Schweifer, N., Varecka, R., Sommergruber, W., Mikulits, W., & Schreiber, M. (2007): Impact of constitutive IGF1/IGF2 stimulation on the transcriptional program of human breast cancer cells. Carcinogenesis, 28(1): 49-59.
Doi: https://doi.org/10.1093/carcin/bgl091
[506]
Spaderna, S., Schmalhofer, O., Hlubek, F., Berx, G., Eger, A., Merkel, S., Jung, A., Kirchner, T., & Brabletz, T. (2006): A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology, 131(3): 830–840.
Doi: https://doi.org/10.1053/j.gastro.2006.06.016
[505]
Stary, M., Pasteiner, W., Summer, A., Hrdina, A., Eger, A., & Weitzer, G. (2005): Parietal endoderm secreted SPARC promotes early cardiomyogenesis in vitro. Experimental cell research, 310(2): 331-43.
Doi: https://doi.org/10.1016/j.yexcr.2005.07.013
[496]
Eger, A., Mikulits, W. (2005): Models of Epithelial to Mesenchymal Transition. Drug Discovery Today: Disease Models, 2(1): 57-63.
Doi: https://doi.org/10.1016/j.ddmod.2005.04.001
[495]
Eger, A., Aigner, K., Sonderegger, S., Dampier, B., Oehler, S., Schreiber, M., Berx, G., Cano, A., Beug, H., & Foisner, R. (2005): DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene, 24(14): 2375-85.
Doi: https://doi.org/10.1038/sj.onc.1208429
[494]
Eger, A., Stockinger, A., Park, J., Langkopf, E., Mikula, M., Gotzmann, J., Mikulits, W., Beug, H., & Foisner, R. (2004): β-catenin and TGFβ signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition. Oncogene, 23(15): 2672-2680.
Doi: https://doi.org/10.1038/sj.onc.1207416
[493]
Gotzmann, J., Mikula, M., Eger, A., Schulte-Hermann, R., Foisner, R., Beug, H., & Mikulits, W. (2004): Molecular aspects of epithelial cell plasticity: implications for local tumor invasion and metastasis. Mutation research, 566(1): 9–20.
Doi: https://doi.org/10.1016/s1383-5742(03)00033-4
[492]
Stockinger, A., Eger, A., Wolf, J., Beug, H., & Foisner, R. (2001): E-cadherin regulates cell growth by modulating proliferation-dependent beta-catenin transcriptional activity. The Journal of cell biology, 154(6): 1185–1196.
Doi: https://doi.org/10.1083/jcb.200104036
[491]
Eger A. and Foisner R. (2000): Dynamic and cross talk of junctional proteins: a molecular basis for the regulation of cell adhesion and epithelial polarity. Protoplasma, 211(3-4): 125-133.
[490]
Eger, A., Stockinger, A., Schaffhauser, B., Beug, H., & Foisner, R. (2000): Epithelial mesenchymal transition by c-Fos estrogen receptor activation involves nuclear translocation of beta-catenin and upregulation of beta-catenin/lymphoid enhancer binding factor-1 transcriptional activity. The Journal of cell biology, 148(1): 173-188.
Doi: https://doi.org/10.1083/jcb.148.1.173
[489]
Gotzmann, J., Eger, A., Meissner, M., Grimm, R., Gerner, C., Sauermann, G., & Foisner, R. (1997): Two-dimensional electrophoresis reveals a nuclear matrix-associated nucleolin complex of basic isoelectric point. Electrophoresis, 18(14): 2645–2653.
Doi: https://doi.org/10.1002/elps.1150181421
[488]
Eger, A., Stockinger, A., Wiche, G., & Foisner, R. (1997): Polarisation-dependent association of plectin with desmoplakin and the lateral submembrane skeleton in MDCK cells. Journal of cell science, 110: 1307-1316.
Prof.(FH) Priv. Doz. Mag. Dr. Andreas Eger
E
Head of Research Institute Krems Bioanalytics / Professor Department...

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