Over the last decade personalised medicine has become increasingly important in the fields of pharmacogenetics, pharmacogenomics, clinical diagnostics, and in particular chronopharmacology, which is concerned with the optimal point in time for drug delivery. However, with respect to therapeutic interventions (in a clinical context), there has been virtually no inquiry into the most beneficial time to give therapy in relation to a patient’s chronobiological rhythms. This project focused on the question of the ideal time to administer therapy in relation to individual biological rhythms, measured using heart rate variability (HRV).
The primary aim was to establish how individual circadian and ultradian rhythms could be represented most effectively by means of HRV analysis.
The project was financed by the Science and Research Department (K 3) of the Province of Lower Austria.